Genomic analysis of metastasis reveals an essential role for RhoC
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Summary
An in vivo selection scheme is used to select highly metastatic melanoma cells to identify families of genes involved in a process, not just single genes, and can indicate which molecular and cellular events might be important in complex biological processes such as metastasis.
- Type
- article
- Published
- 2000-08-03
- Cited by
- 1,522
- References
- 33
- OpenAlex
- https://openalex.org/W1949238489
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4301092
Keywords
RhoC, Metastasis, Biology, Phenotype, Gene
References
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- Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-met signalling in human cells concomitant with induction of the urokinase proteolysis network
Cited by
- Expression of Functional Chemokine Receptors CXCR3 and CXCR4 on Human Melanoma Cells*
- Suppression of tissue factor expression, cofactor activity, and metastatic potential of murine melanoma cells by the N‐terminal domain of adenovirus E1A 12S protein
- Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer
- A lymph node metastatic mouse model reveals alterations of metastasis‐related gene expression in metastatic human oral carcinoma sublines selected from a poorly metastatic parental cell line
- Actin, microtubules and focal adhesion dynamics during cell migration.
- Upregulation of galectin-7 in murine lymphoma cells is associated with progression toward an aggressive phenotype
- Tumour-cell invasion and migration: diversity and escape mechanisms
- Comparative evaluation of four trityl‐type amidomethyl polystyrene resins in Fmoc solid phase peptide synthesis
- Expression and regulation of phospholipase D isoenzymes in human melanoma cells and primary melanocytes
- Identification of differentially expressed genes in human lung squamous cell carcinoma using suppression subtractive hybridization.
- Regulation of actin-based cell migration by cAMP/PKA.
- Profiling the Evolution of Human Metastatic Bladder Cancer
- Identification and Testing of a Gene Expression Signature of Invasive Carcinoma Cells within Primary Mammary Tumors
- Control of cell migration: a tumour suppressor function for p53?
- Gene expression profiling of primary cutaneous melanoma and clinical outcome.
- The role of protein geranylgeranylation in prostate cancer
- Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation
- Regional lymph node metastases; a singular manifestation of the process of clinical metastases in cancer: contemporary animal research and clinical reports suggest unifying concepts.
- The genetics of malignant melanoma.
- Metastasis: from dissemination to organ-specific colonization
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