Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Keywords

DNA damage, Senescence, Carcinogenesis, Oncogene, Biology

References

• Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.Lise Lamarche, Linda Covit, Lourdes Cué — 2003
• ATM signaling and 53BP1.Seongmin Kim, Sangsin Na — 2005
• The Progression in the Mouse Skin Carcinogenesis Model Correlates With ERK1/2 SignalingKostas D. Katsanakis, Vassilis G. Gorgoulis, Athanasios G. Papavassiliou — 2002
• Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas: synergistic effect with mutant p53 on tumor growth and chromosomal instability--evidence of E2F-1 transcriptional control over hCdt1.Panagiotis Karakaidos, Stavros Taraviras, Leandros Vassiliou — 2004
• A DNA damage checkpoint response in telomere-initiated senescenceFabrizio d’Adda di Fagagna, Philip M. Reaper, Lorena Clay-Farrace — 2003
• DNA damage foci at dysfunctional telomeres.Hiroyuki Takai, Agata Smogorzewska, Titia de Lange — 2003
• Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage.Elke Raderschall, Efim I. Golub, Thomas Haaf — 1999
• Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesisZhenbang Chen, Lloyd C. Trotman, David R. Shaffer — 2005
• Intrinsic tumour suppressionScott W. Lowe, Enriqué Cepero, Gérard I. Evan — 2004
• Visualization of Altered Replication Dynamics after DNA Damage in Human Cells*Catherine J. Merrick, Dean A. Jackson, John F.X. Diffley — 2004
• Mos induces the in vitro activation of mitogen-activated protein kinases in lysates of frog oocytes and mammalian somatic cells.Ellen K. Shibuya, Joan Ruderman — 1993
• Checkpoint responses to replication fork barriers.Sarah Lambert, Antony M. Carr — 2005
• Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).Utz Herbig, Wendy A. Jobling, Benjamin P.C. Chen — 2004
• DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.Aldo Di Leonardo, Steven P. Linke, Kristie Clarkin — 1994
• Improved cervical smear assessment using antibodies against proteins that regulate DNA replication.Gareth Williams, Piotr Romanowski, Lesley S. Morris — 1998
• A System for Stable Expression of Short Interfering RNAs in Mammalian CellsThijn R. Brummelkamp, René Bernards, Reuven Agami — 2002
• DNA damage response as a candidate anti-cancer barrier in early human tumorigenesisJiřina Bártková, Zuzana Hořejšı́, Karen Koed — 2005
• Tumour biology: Senescence in premalignant tumoursManuel Collado, Jesús Gil, Alejo Efeyan — 2005
• Oncogene-induced senescence as an initial barrier in lymphoma developmentMelanie Braig, Soyoung Lee, Christoph Loddenkemper — 2005
• Activation of the DNA damage checkpoint and genomic instability in human precancerous lesionsVassilis G. Gorgoulis, Leandros-Vassilios Vassiliou, Panagiotis Karakaidos — 2005

Cited by

• Development of an shRNA screen to identify mediators of cellular senescence in human breast epithelial cellsK. Wanek — 2011
• Developing a systems-based understanding of hematopoietic stem cell cycle control.Ka Tat Siu, Alex C. Minella — 2014
• Ionizing radiation and aging: rejuvenating an old ideaRichard B. Richardson — 2009
• The Vitamin D Receptor as Tumor Suppressor in Skin.Daniel D. Bikle — 2020
• The genome and epigenome of malignant melanomaAwais Rashid — 2007
• Stemming out of a new PML era?И.М. Джукгаева, А.Н. Чотчаева, Е.О. Афаунова — 2009
• The many facets of the Tim-Tipin protein families’ roles in chromosome biologyStefan Leíble, Olaf Sosnitza — 2010
• Transcriptional regulation of cellular senescenceIvan Widjaya — 2011
• Senescence and pre-malignancy: how do tumors progress?Robert K. Eskew — 2011
• CLCA2 as a p53-inducible senescence mediator.一彦 石原, 安弘 延藤, 清吾 佐藤 — 2012
• Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progressionLuísa Maria Veloso de Andrade Pires Pinto — 2012
• Wnt Antagonist SFRP1 Functions as a Secreted Mediator of SenescenceJulio Moreno Aragoneses — 2012
• Bexarotene Induces Cellular Senescence in MMTV-Neu Mouse Model of Mammary CarcinogenesisSusan Srubek Donahoe — 2013
• Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediatesLaura Freixas — 2013
• The DNA damage checkpoint response to replication stress: A Game of ForksRachel Jossen, Rodrigo Bermejo — 2013
• Working hard for recovery: mitotic kinases in the DNA damage checkpointLilian Moncrieff — 2013
• Dissecting the telomere-independent pathways underlying human cellular senescenceEmilie Rovillain — 2011
• Cdc6 cooperates with c-Myc to promote genome instability and epithelial to mesenchymal transition (EMT) in zebrafish史彦 松山, 雅義 谷下 — 2014
• Role of sirtuins in chronic obstructive pulmonary diseaseJosé Luis Martín Martín — 2015
• Trial Watch: Targeting ATM–CHK2 and ATR–CHK1 pathways for anticancer therapy史朗 中村 — 2015

Related papers

• Retarding the cellular senescence by Epithalon and changes of telomere length and telomerase activity in the retarding processTong Shi-liang — 2007
• Five dysfunctional telomeres predict onset of senescence in human cellsZeenia Kaul, Anthony J. Cesare, Lily I. Huschtscha — 2011
• Senescence Induced by Altered Telomere State, Not Telomere LossJan Karlseder, Agata Smogorzewska, Titia de Lange — 2002
• Cellular senescence, telomere recombination and maintenanceQin Yang — 2009
• Telomere length profiles in primary human peritoneal mesothelial cells are consistent with senescence.Melisa Lopez-Anton, A Hatz Rudolf, Duncan M. Baird — 2017
• Effects of initial telomere length distribution on senescence onset and heterogeneitySarah Eugène, Thibault Bourgeron, Zhou Xu — 2016
• Tumor suppression by p53: making cells senescentYingjuan Qian, Xinbin Chen — 2010