Dissecting the telomere-independent pathways underlying human cellular senescence
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Summary
Novel markers involved in senescence are uncovered as well as identifying that both activation of p53 and pRb pathway result in activation of NF-κB signalling which promotes senescenced cells.
- Published
- 2011-03-28
- Cited by
- 1
- References
- 639
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:81936324
References
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- Induction of Cachexia in Mice by Systemically Administered Myostatin
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- The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.
- Identification of differentially expressed genes in human lung squamous cell carcinoma using suppression subtractive hybridization.
- Insights into Aging Obtained from p53 Mutant Mouse Models
- Exploration of replicative senescence-associated genes in human dermal fibroblasts by cDNA microarray technology.
- Gene expression profile analysis in human hepatocellular carcinoma by cDNA microarray.
- Adenovirus E1A targets key regulators of cell proliferation.
- Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen.
- The three transforming regions of SV40 T antigen are required for immortalization of primary mouse embryo fibroblasts.
- Inhibition of apoptosis by the retinoblastoma gene product.
- RNA interference in mammalian cell systems.
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