The Vitamin D Receptor as Tumor Suppressor in Skin.
Explore this paper's citation graph
Summary
It is concluded that vitamin D signaling in the skin suppresses UVR-induced epidermal tumor formation and the roles of hedgehog, Wnt/β-catenin, and hyaluronan/CD44 pathways in mediating vitamin D regulation of proliferation/differentiation are discussed.
- Type
- review
- Published
- 2020-01-01
- Cited by
- 14
- References
- 218
- OpenAlex
- https://openalex.org/W7699552
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:221636399
Keywords
Calcitriol receptor, Epidermis (zoology), Cancer research, Carcinogenesis, Hair follicle
References
- UV-B radiation induces the expression of antimicrobial peptides in human keratinocytes in vitro and in vivo.
- Vitamin D and the skin: Physiology and pathophysiology
- Selective Hyaluronan–CD44 Signaling Promotes miRNA-21 Expression and Interacts with Vitamin D Function during Cutaneous Squamous Cell Carcinomas Progression Following UV Irradiation
- MDM2 binds and inhibits vitamin D receptor
- Topical calcitriol protects from UV‐induced genetic damage but suppresses cutaneous immunity in humans
- Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization.
- Inhibition of epidermal Langerhans cell function by low dose ultraviolet B radiation. Ultraviolet B radiation selectively modulates ICAM-1 (CD54) expression by murine Langerhans cells.
- 1,25-Dihydroxyvitamin D production and receptor binding in human keratinocytes varies with differentiation.
- Topically Applied 1,25-Dihydroxyvitamin D3 Enhances the Suppressive Activity of CD4+CD25+ Cells in the Draining Lymph Nodes1
- Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB.
- Immunologic parameters of ultraviolet carcinogenesis.
- Decreased DNA repair but normal apoptosis in ultraviolet-irradiated skin of p53-transgenic mice.
- Nonmelanoma skin cancer after renal transplantation: a single‐center experience in 1736 transplantations
- 1,25-dihydroxyvitamin D3 receptors in human epithelial cancer cell lines.
- The first genome-wide view of vitamin D receptor locations and their mechanistic implications.
- Immunosuppressive actions of 1,25-dihydroxyvitamin D3: preferential inhibition of Th1 functions.
- Signature of VDR miRNAs and epigenetic modulation of vitamin D signaling in melanoma cell lines.
- Antigenicity of murine skin tumors induced by ultraviolet light.
- NER and DDR: Classical music with new instruments
- Long noncoding RNAs: Cellular address codes in development and disease
Cited by
- The Role of the Vitamin D Receptor in the Pathogenesis, Prognosis, and Treatment of Cutaneous Melanoma
- KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis
- Hypovitaminosis D exacerbates the DNA damage load in human uterine fibroids, which is ameliorated by vitamin D3 treatment
- Photoprotective properties of vitamin D and lumisterol hydroxyderivatives
- Vitamin D, autoimmunity and immune-related adverse events of immune checkpoint inhibitors
- Lessons Learned from Paleolithic Models and Evolution for Human Health: A Snap Shot on Beneficial Effects and Risks of Solar Radiation.
- Vitamin D receptor promotes global nucleotide excision repair by facilitating XPC dissociation from damaged DNA.
- Vitamin D regulation of and by long non coding RNAs.
- The Impact of Vitamin D on Skin Aging
- Serum Vitamin D Levels Explored in the Latvian Cohort of Patients with Basal Cell Carcinoma Linked to the Sonic Hedgehog and Vitamin D Binding Protein Cutaneous Tissue Indices
- Significant association of Poly-A and Fok1 polymorphic alleles of the vitamin D receptor with vitamin D serum levels and incidence of squamous cutaneous neoplasia
- Sunlight Vitamin D and Skin Cancer
- DELETION OF VITAMIN D RECEPTOR WITH CALCIUM SENSING RECEPTOR IN KERATINOCYTES PROMOTES EPIDERMAL TUMORIGENESIS BY LIMITING DNA REPAIR AND OXIDATIVE STRESS RESPONSE GENES.
- Dermatoloji ve Kozmetolojide D Vitamini
- Vitamin D, Calcium, and the Epidermis
- Vitamin D Deficiency and Medically Assisted Reproduction
Related papers
- Chemopreventive potential of 18beta-glycyrrhetinic acid: an active constituent of liquorice, in 7,12-dimethylbenz(a)anthracene induced hamster buccal pouch carcinogenesis.
- DMBA와 TPA에 의해 유도된 ICR Mice의 생식기 종양에서의 ras 암유전자 발현
- The Effects of Progesterone and Ovariectomy on Mammary Tumours Induced by 7,12‐Dimethylbenz(A) Anthracene in Sprague‐Dawley Rats
- A simple and sensitive method to detect vitamin D receptor expression in various disease models using stool samples
- Two-phase carcinogenesis on the DMBA induced carcinoma
- Tumor associated proteins of rat skin tumor induced by 7,12-dimethylbenz[a]anthracene.
- Promotion of mouse two-stage skin carcinogenesis by diacylglycerol-rich edible oil.
- Electro-Acupuncture Therapy Increases Serum Interferon-γ Levels in Rats with 7, 12 Dimethylbenz(α)anthracene (DMBA)-Induced Breast Tumors
- The effect of flavonoids on regenerated hair follicles with pigmentation