Mechanisms of mitophagy
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Summary
Mitophagy, the specific autophagic elimination of mitochondria, has been identified in yeast, and in mammals during red blood cell differentiation, mediated by NIP3-like protein X (NIX; also known as BNIP3L).
- Type
- review
- Published
- 2011-01-01
- Cited by
- 3,228
- References
- 73
- Access
- Open access
- OpenAlex
- https://openalex.org/W2038976751
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3353313
Keywords
Mitophagy, PINK1, Parkin, Autophagy, Cell biology
References
- Pexophagy in Pichia pastoris.
- Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
- p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria
- Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion.
- Aup1p, a Yeast Mitochondrial Protein Phosphatase Homolog, Is Required for Efficient Stationary Phase Mitophagy and Cell Survival*
- Eaten alive: a history of macroautophagy
- NIX is required for programmed mitochondrial clearance during reticulocyte maturation
- Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy.
- PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy
- The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
- Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin
- A genomic screen for yeast mutants defective in mitophagy
- The PINK1/Parkin pathway regulates mitochondrial morphology
- Nix directly binds to GABARAP: A possible crosstalk between apoptosis and autophagy
- The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation.
- Mitochondrial disappearance from cells: a clue to the role of autophagy in programmed cell death and disease?
- PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice
- Dynamics and diversity in autophagy mechanisms: lessons from yeast
- Nix Is Critical to Two Distinct Phases of Mitophagy, Reactive Oxygen Species-mediated Autophagy Induction and Parkin-Ubiquitin-p62-mediated Mitochondrial Priming*
- Atg32 is a mitochondrial protein that confers selectivity during mitophagy
Cited by
- Characterization of the Role of Mitochondrial Function During Tumor Development and Muscle Wasting
- Autophagy in Pancreatic Cancer
- Analysis of neural subtypes reveals selective mitochondrial dysfunction in dopaminergic neurons from parkin mutants
- Mitochondrial Control of Cellular Life, Stress, and Death
- Selective Autophagy: talking with the UPS
- Mitochondrial Fusion Proteins and Human Diseases
- Drosophila Erect wing (Ewg) controls mitochondrial fusion during muscle growth and maintenance by regulation of the Opa1-like gene
- Mitochondria: FKBP38 and mitochondrial degradation.
- Impaired proteostasis: role in the pathogenesis of diabetes mellitus
- Intramitochondrial recruitment of endolysosomes mediates Smac degradation and constitutes a novel intrinsic apoptosis antagonizing function of XIAP E3 ligase
- Parkin‐independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain
- Overexpression of Rcan1-1L Inhibits Hypoxia-Induced Cell Apoptosis through Induction of Mitophagy
- Synthetic quantitative array technology identifies the Ubp3-Bre5 deubiquitinase complex as a negative regulator of mitophagy.
- Targeting skeletal muscle mitochondria to prevent type 2 diabetes in youth.
- Inactivation of 3-hydroxybutyrate dehydrogenase 2 delays zebrafish erythroid maturation by conferring premature mitophagy
- Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy
- A neuronal network of mitochondrial dynamics regulates metastasis
- Autophagy and the Cell Cycle: A Complex Landscape
- Parkin clearance of dysfunctional mitochondria regulates ROS levels and increases survival of human chondrocytes
- A Method for In Vivo Induction and Ultrastructural Detection of Mitophagy in Sertoli Cells.
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- Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
- Commitment in the PINK1/Parkin mitophagy decision circuit
- PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease
- Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson’s disease
- Vps13D functions in a Pink1-dependent and Parkin-independent mitophagy pathway