The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

Keywords

PINK1, Parkin, Mitochondrial fission, mitochondrial fusion, Biology

References

• Parkinson's Disease Mechanisms and ModelsWilliam T. Dauer, Serge Przedborski — 2003
• The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeastWilliam Bleazard, J. Michael McCaffery, Edward J. King — 1999
• Mutations in the parkin gene cause autosomal recessive juvenile parkinsonismTohru Kitada, Shuichi Asakawa, Nobutaka Hattori — 1998
• Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis.J. William Langston, Philip L. Ballard, James W. Tetrud — 1983
• Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions.Patrik Verstreken, Cindy V. Ly, Koen J. T. Venken — 2005
• The Drosophila parkin homologue is required for normal mitochondrial dynamics during spermiogenesis.Maria Giovanna Riparbelli, Giuliano Callaini — 2007
• Fzo1p Is a Mitochondrial Outer Membrane Protein Essential for the Biogenesis of Functional Mitochondria in Saccharomyces cerevisiae*Doron Rapaport, Michael Brunner, Walter Neupert — 1998
• The PINK1/Parkin pathway regulates mitochondrial morphologyAngela C. Poole, Ruth E. Thomas, Laurie A. Andrews — 2008
• Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease.Mark Dodson, Ming Guo — 2007
• Early-onset parkinsonism associated with PINK1 mutations: Frequency, genotypes, and phenotypesMohammed Sunbulli, Imad Zak, Seemant Chaturvedi — 2005
• Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkinJeehye Park, Sung Bae Lee, Sungkyu Lee — 2006
• The Molecular Mechanisms of OPA1-Mediated Optic Atrophy in Drosophila Model and Prospects for Antioxidant TreatmentWill Yarosh, Jessica P. Monserrate, James Jiayuan Tong — 2008
• Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutantsJessica Greene, Alexander J. Whitworth, Isabella J. Kuo — 2003
• Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability.Alexandra Beilina, Marcel van der Brug, Rili Ahmad — 2005
• Understanding the molecular causes of Parkinson's disease.Alison Wood‐Kaczmar, Sonia Gandhi, Nicholas Wood — 2006
• Loss-of-Function of Human PINK1 Results in Mitochondrial Pathology and Can Be Rescued by ParkinNicole Exner, Bettina Treske, Dominik Paquet — 2007
• Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.Andrea H. Brand, Norbert Perrimon — 1993
• Immunohistochemical and subcellular localization of parkin protein: Absence of protein in autosomal recessive juvenile parkinsonism patientsHideki Shimura, Nobutaka Hattori, Shinichiro Kubo — 1999
• Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo.Manuel Rojo, Frédéric Legros, Danielle Château — 2002
• Dnm1p Gtpase-Mediated Mitochondrial Fission Is a Multi-Step Process Requiring the Novel Integral Membrane Component Fis1pAmy D. Mozdy, J. Michael McCaffery, Janet M. Shaw — 2000

Cited by

• PINK1 Defect Causes Mitochondrial Dysfunction, Proteasomal Deficit and α-Synuclein Aggregation in Cell Culture Models of Parkinson's DiseaseAdam Hoover, Anirud Singh, Stephanie R. Fishel — 2009
• Deletion of a Novel F-Box Protein, MUS-10, in Neurospora crassa Leads to Altered Mitochondrial Morphology, Instability of mtDNA and SenescenceCarlo Ghisalberti — 2010
• Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics.Yeni García Pérez, Guillermo Alomá Sarría — 2010
• Analysis of neural subtypes reveals selective mitochondrial dysfunction in dopaminergic neurons from parkin mutantsJonathon L. Burman, Selina Yu, Angela C. Poole — 2012
• The Parkinson’s gene PINK1 regulates cell cycle progression and promotes cancer-associated phenotypesMonesha Gupta‐Malhotra, Archana Dave, Brian Sturhan — 2014
• Mitochondrial importance in Alzheimer's, Huntington's and Parkinson's diseases.Sónia C. Correia, Renato X. Santos, George Perry — 2012
• Valosin-containing protein (VCP/p97) inhibitors relieve Mitofusin-dependent mitochondrial defects due to VCP disease mutantsMarissa S. Edwards, Neal M. Ashkanasy, John E. Gardner — 2017
• A role for Saccharomyces cerevisiae Centrin (Cdc31) in mitochondrial function and biogenesisRichard C. Gormley — 2018
• The Interplay among PINK1/PARKIN/Dj-1 Network during Mitochondrial Quality Control in Cancer Biology: Protein Interaction AnalysisKathleen Underwood — 2018
• The PINK1 repertoire: Not just a one trick ponyWaspiah Waspiah — 2021
• Mitochondrial Dynamics in Retinal Ganglion Cell Axon Regeneration and Growth Cone GuidanceKira L. Lathrop, Michael B. Steketee — 2013
• Mécanismes moléculaires et de signalisation induits par le stress oxydatif dans des modèles in vivo de la maladie de Parkinson chez la drosophile : intoxication au paraquat et expression de l'α-synucléineMarlène Cassar — 2012
• Elucidating the functional interplay between Parkinson’s disease-related proteins and the mitochondrionGiulia Bertolin — 2013
• Investigation of the mitochondrial functions of proteins genetically associated with Parkinson's DiseaseV. Burchell — 2012
• The Impact of Genetic Research on Our Understanding of Parkinson’s DiseaseIan Martin, Valina L. Dawson, Ted M. Dawson — 2010
• Regulation of the ubiquitin RING E3 ligase ParkinV. Chaugule — 2011
• What have we learned from Drosophila models of Parkinson's disease?Ming Guo — 2010
• Zebrafish as a Model for the Study of Parkinson’s DiseaseYanwei Xi — 2011
• The mitochondrial pathways of apoptosis.Jérôme Estaquier, François M. Vallette, Jean‐Luc Vayssière — 2012
• Mitochondrial Involvement in Neurodegeneration and AgingAlicia M. Pickrell — 2012

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