Inactivation of 3-hydroxybutyrate dehydrogenase 2 delays zebrafish erythroid maturation by conferring premature mitophagy
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Summary
Reestablishment of bdh2 restores mitochondrial function, prevents premature mitochondrial degradation, promotes erythroid development, and reverses altered gene expression, demonstrating that mitochondrial communication with the nucleus is critical for erythyroid development.
- Type
- article
- Published
- 2016-02-29
- Cited by
- 25
- References
- 34
- Access
- Open access
- OpenAlex
- https://openalex.org/W2290802470
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1099497
Keywords
Zebrafish, Biology, Mitophagy, Mitochondrion, Cell biology
References
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- The myb gene family in cell growth, differentiation and apoptosis
- HuR and mRNA stability
- Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation.
- A Mammalian Siderophore Synthesized by an Enzyme with a Bacterial Homologue Involved in Enterobactin Production
- Distinct Functions for Different scl Isoforms in Zebrafish Primitive and Definitive Hematopoiesis
- Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol
- Measuring oxidative phosphorylation in human skin fibroblasts.
- The ‘definitive’ (and ‘primitive’) guide to zebrafish hematopoiesis
- Mechanisms of mammalian iron homeostasis
- Mechanisms of mitophagy
- Zebrafish in hematology: sushi or science?
- B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development
- Elavl1a regulates zebrafish erythropoiesis via posttranscriptional control of gata1.
- Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor.
- Isolation and functional characterization of human erythroblasts at distinct stages: implications for understanding of normal and disordered erythropoiesis in vivo.
Cited by
- Lipocalin 2: An Emerging Player in Iron Homeostasis and Inflammation.
- A Red Carpet for Iron Metabolism
- Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics
- “Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels
- A specialized pathway for erythroid iron delivery through lysosomal trafficking of transferrin receptor 2.
- Validation of Osteogenic Properties of Cytochalasin D by High-Resolution RNA-Sequencing in Mesenchymal Stem Cells Derived from Bone Marrow and Adipose Tissues
- Novel Insights in Ankylosing Spondylitis Biology: Mouse and Human Studies
- The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation
- Fundc1 is necessary for proper body axis formation during embryogenesis in zebrafish
- Selective autophagy: the rise of the zebrafish model
- Bdh2 Deficiency Promotes Endoderm-Biased Early Differentiation of Mouse Embryonic Stem Cells
- zmiz1a zebrafish mutants have defective erythropoiesis, altered expression of autophagy genes, and a deficient response to vitamin D
- Mitochondrial connections with immune system in Zebrafish
- Genome-wide association study of liver fat, iron, and extracellular fluid fraction in the UK Biobank
- Comprehensive Profiling of Mammalian Tribbles Interactomes Implicates TRIB3 in Gene Repression
- Understanding the Potential and Risk of Bacterial Siderophores in Cancer
- Autophagy regulated by the HIF/REDD1/mTORC1 signaling is progressively increased during erythroid differentiation under hypoxia
- Erythropoiesis in Teleost Fishes: The Fantastic Biological Process
- Identification of the Regulatory Elements and Protein Substrates of Lysine Acetoacetylation
- Ketogenesis supports hepatic polyunsaturated fatty acid homeostasis via fatty acid elongation
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