Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.
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Summary
Tcf1 may act as a feedback repressor of beta-catenin-Tcf4 target genes and thus may cooperate with APC to suppress malignant transformation of epithelial cells.
- Type
- article
- Published
- 1999-09-17
- Cited by
- 502
- References
- 42
- OpenAlex
- https://openalex.org/W2014748872
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:113272
Keywords
TCF4, Catenin, Cancer research, Beta-catenin, Transcription factor
References
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- Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.
- β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
- The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization.
- Molecular determinants of dysplasia in colorectal lesions.
- Apoptosis and APC in colorectal tumorigenesis.
- Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
- Screening for colorectal cancer.
- Wnt signaling: a common theme in animal development.
- Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients.
- Identification and characterization of the familial adenomatous polyposis coli gene
- Functional interaction of β-catenin with the transcription factor LEF-1
- A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse.
- An HMG-box-containing T-cell factor required for thymocyte differentiation
- Identification of c-MYC as a target of the APC pathway.
- ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias.
- Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15
- Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β
- The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation.
Cited by
- Genetics of hereditary colon cancer - a basis for prevention?
- E-cadherin regulates cell growth by modulating proliferation-dependent β-catenin transcriptional activity
- Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors
- Total Synthesis and Mechanism of Action Studies on the Antitumor Alkaloid (-)-Agelastatin A
- Hindgut defects and transformation of the gastro‐intestinal tract in Tcf4−/−/Tcf1−/− embryos
- Wnt/β-catenin signaling induces the transcription of cystathionine-γ-lyase, a stimulator of tumor in colon cancer.
- A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations
- TCF/LEF Transcription Factors: An Update from the Internet Resources
- β-catenin is required for taste bud cell renewal and behavioral taste perception in adult mice
- Pja2 Inhibits Wnt/β-catenin Signaling by Reducing the Level of TCF/LEF1
- Wnt Effector TCF4 Is Dispensable for Wnt Signaling in Human Cancer Cells
- Characterization of drosophila nemo kinase, a conserved modulator of Wnt and TGF? signal transduction
- Wnt of the Two Horizons: Putting Stem Cell Self-Renewal and Cell Fate Determination into Context
- Beta-catenin in liver: A matter of life and death
- TCFs and Wnt/β-catenin signaling: more than one way to throw the switch.
- Rodzinna polipowatość gruczolakowata jelita grubego
- Genetic and Molecular Characterization of ISWI Family Chromatin Remodelers in Wingless Signaling.
- A T-box Protein Interacting with the TCF Transcriptional Switch of Wnt Signaling in Xenopus Dorsal Axis Development.
- Regulation of neuritogenesis in neuroblastoma cells by components of the WNT signalling pathway.
- The Transcriptomic and Genomic Analysis of Lamin A/C Expression in the Colon and in Colorectal Cancer
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