Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
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Summary
Results indicate that regulation of β-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or β- catenin.
- Type
- article
- Published
- 1997-03-21
- Cited by
- 3,241
- References
- 25
- OpenAlex
- https://openalex.org/W1967137553
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26754292
Keywords
Adenomatous polyposis coli, Catenin, Colorectal cancer, Cancer research, Beta-catenin
References
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- The APC gene product associates with microtubules in vivo and promotes their assembly in vitro.
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- Identification and characterization of the familial adenomatous polyposis coli gene
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- A repeating amino acid motif shared by proteins with diverse cellular roles.
- The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.
- APC mutations occur early during colorectal tumorigenesis
- Phosphorylation of the Drosophila adherens junction protein Armadillo: roles for wingless signal and zeste-white 3 kinase.
- Mutations of the APC adenomatous polyposis coli) gene
- Dimer formation by an N-terminal coiled coil in the APC protein.
- Identification of FAP locus genes from chromosome 5q21.
- Association of the APC gene product with beta-catenin.
- Binding of APC to the Human Homolog of the Drosophila Discs Large Tumor Suppressor Protein
- XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos.
- Familial infiltrative fibromatosis (desmoid tumours) (MIM135290) caused by a recurrent 3' APC gene mutation.
- Deletion of an amino-terminal sequence beta-catenin in vivo and promotes hyperphosporylation of the adenomatous polyposis coli tumor suppressor protein
Cited by
- APC and DNA demethylation in cell fate specification and intestinal cancer.
- Expansion of CpG methylation in the SFRP2 promoter region during colorectal tumorigenesis.
- Mechanical induction in embryonic development and tumor growth integrative cues through molecular to multicellular interplay and evolutionary perspectives.
- Guidance for life, cell death, and colorectal neoplasia by netrin dependence receptors.
- Development The Natural History of Genes
- APC and β-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers
- The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction.
- Dysplasia and cancer in the dextran sulfate sodium mouse colitis model. Relevance to colitis-associated neoplasia in the human: a study of histopathology, B-catenin and p53 expression and the role of inflammation.
- Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis.
- Nuclear-cytoplasmic shuttling of APC regulates β-catenin subcellular localization and turnover
- Regulation of transcription factors by protein degradation
- Molecular pathogenesis of oral squamous carcinoma
- Tumor Suppressor Pten Inhibits Nuclear Accumulation of β-Catenin and T Cell/Lymphoid Enhancer Factor 1–Mediated Transcriptional Activation
- Metastasis-inducing dna regulates the expression of the osteopontin gene by binding the transcription factor Tcf-4.
- Different patterns of β‐catenin expression in gastric carcinomas: relationship with clinicopathological parameters and prognostic outcome
- Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation.
- Exclusion of Madh2, Madh4, and Madh7 as candidates for the modifier of Min 2 (Mom2) locus
- Downregulation of E-cadherin and its undercoat proteins in pituitary growth hormone cell adenomas with prominent fibrous bodies
- Activation of c-Met in colorectal carcinoma cells leads to constitutive association of tyrosine-phosphorylated β-catenin
- Tumor formation is correlated with expression of β‐catenin‐accumulated crypts in azoxymethane‐induced colon carcinogenesis in mice
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