Characterization of drosophila nemo kinase, a conserved modulator of Wnt and TGF? signal transduction
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Summary
The results indicate that Nemo acts as an intracellular feedback inhibitor of Wg during wing development and that it is a novel Wg target gene, and a novel crosstalk between Wg and Dpp signaling is unveiled, in which Wg-dependent gene expression is suppressed by ectopic DPP signaling.
- Type
- dissertation
- Published
- 2005-01-01
- Cited by
- 0
- References
- 138
- Access
- Open access
- OpenAlex
- https://openalex.org/W34377079
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:81592767
Keywords
Wnt signaling pathway, Signal transduction, Cell biology, Phosphorylation, Biology
References
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- TAK1 is a ubiquitin-dependent kinase of MKK and IKK
- A structural basis for mutational inactivation of the tumour suppressor Smad4
- Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4
- Cross-regulation of the Wnt signalling pathway: a role of MAP kinases.
- The segment polarity gene armadillo interacts with the wingless signaling pathway in both embryonic and adult pattern formation.
- Repression of Teashirt marks the initiation of wing development.
- Smad regulation in TGF-beta signal transduction.
- Context-dependent relationships between the BMPs gbb and dpp during development of the Drosophila wing imaginal disk.
- The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4.
- Controlling TGF-beta signaling.
- An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling
- Involvement of NLK and Sox11 in neural induction in Xenopus development
- Production of a DPP activity gradient in the early Drosophila embryo through the opposing actions of the SOG and TLD proteins.
- Notch and Wingless modulate the response of cells to Hedgehog signalling in the Drosophila wing.
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