Functional interaction of β-catenin with the transcription factor LEF-1
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Summary
β-catenin regulates gene expression by direct interaction with transcription factors such as LEF-1, providing a molecular mechanism for the transmission of signals from cell-adhesion components or wnt protein to the nucleus.
- Type
- article
- Published
- 1996-08-15
- Cited by
- 2,716
- References
- 29
- OpenAlex
- https://openalex.org/W1989215255
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4369341
Keywords
Cell biology, Enhancer, Transcription factor, Xenopus, Wnt signaling pathway
References
- A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin.
- Experiments in molecular genetics
- E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton
- Overexpression of cadherins and underexpression of β-catenin inhibit dorsal mesoderm induction in early Xenopus embryos
- A novel genetic system to detect proteinprotein interactions
- LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected].
- Structural basis for DNA bending by the architectural transcription factor LEF-1
- A repeating amino acid motif shared by proteins with diverse cellular roles.
- Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis.
- Dominant negative expression of a cytoplasmically deleted mutant of XB/U-cadherin disturbs mesoderm migration during gastrulation in Xenopus laevis.
- A new member of the frizzled family from Drosophila functions as a Wingless receptor
- Bending of DNA by gene-regulatory proteins: construction and use of a DNA bending vector.
- The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures.
- dishevelled and armadillo act in the Wingless signalling pathway in Drosophila
- A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer.
- Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein.
- Plakoglobin: a protein common to different kinds of intercellular adhering junctions.
- Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs.
- Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development.
- The Nuclear Localization Signal of Lymphoid Enhancer Factor-1 Is Recognized by Two Differentially Expressed Srp1-Nuclear Localization Sequence Receptor Proteins (*)
Cited by
- beta-Catenin is a target for extracellular signals controlling cadherin function: the neurocan-GalNAcPTase connection.
- GATA transcription factors in the developing reproductive system.
- Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart
- Nuclear–Cytoplasmic Shuttling of the Focal Contact Protein, Zyxin: A Potential Mechanism for Communication between Sites of Cell Adhesion and the Nucleus
- Cell adhesion: more than just glue (review).
- The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction.
- Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis.
- Molecular pathogenesis of oral squamous carcinoma
- Transcription factor regulation of B lineage commitment.
- Tumor Suppressor Pten Inhibits Nuclear Accumulation of β-Catenin and T Cell/Lymphoid Enhancer Factor 1–Mediated Transcriptional Activation
- E-cadherin regulates cell growth by modulating proliferation-dependent β-catenin transcriptional activity
- Disulfide Bond Assignments of Secreted Frizzled-related Protein-1 Provide Insights about Frizzled Homology and Netrin Modules*
- Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors
- Wnt signaling during BMP‐2 stimulation of mesenchymal chondrogenesis
- Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation.
- Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge.
- Downregulation of E-cadherin and its undercoat proteins in pituitary growth hormone cell adenomas with prominent fibrous bodies
- Activation of c-Met in colorectal carcinoma cells leads to constitutive association of tyrosine-phosphorylated β-catenin
- β‐catenin–mediated cell‐adhesion is vital for embryonic forebrain development
- MDM2 interacts with and downregulates a sarcomeric protein, TCAP.
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