Identification and characterization of the familial adenomatous polyposis coli gene
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Summary
DNA from 61 unrelated patients with adenomatous polyposis coli (APC) was examined for mutations in three genes located within a 100 kb region deleted in two of the patients, and data have established that DP2.5 is the APC gene.
- Type
- article
- Published
- 1991-08-09
- Cited by
- 2,860
- References
- 26
- OpenAlex
- https://openalex.org/W1979618971
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:38325198
Keywords
Biology, Genetics, Exon, Adenomatous polyposis coli, Gene
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Cited by
- The adenoma‐adenocarcinoma sequence in the large bowel: Variations on a theme
- Familial Pancreatic Cancer: A Family Study
- Tumor suppressor genes.
- beta-Catenin is a target for extracellular signals controlling cadherin function: the neurocan-GalNAcPTase connection.
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- Divergent effects of epidermal growth factor and calcipotriol on human rectal cell proliferation.
- APC mutation in the alternatively spliced region of exon 9 associated with late onset familial adenomatous polyposis
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- Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis.
- Nuchal fibroma should be recognized as a new extracolonic manifestation of Gardner-variant familial adenomatous polyposis.
- Risk factors for rectal cancer morbidity and mortality in patients with familial adenomatous polyposis after colectomy and ileorectal anastomosis
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