Wnt signaling: a common theme in animal development.
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Summary
Current understanding of Wnt function and signaling mechanisms is reviewed in a comparative approach, highlighting novelty and underscoring questions that remain, and putting emphasis on the latest findings.
- Type
- review
- Published
- 1997-12-15
- Cited by
- 2,717
- References
- 189
- Access
- Open access
- OpenAlex
- https://openalex.org/W1975853332
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6033862
Keywords
Wnt signaling pathway, Biology, Caenorhabditis elegans, Signal transduction, Mechanism (biology)
References
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- Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein.
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- Two different thresholds of wingless signalling with distinct developmental consequences in the Drosophila midgut.
- The proto‐oncogene int‐1 encodes a secreted protein associated with the extracellular matrix.
- Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors
- Proximal–distal axis formation in the Drosophila leg
- Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes.
- Wingless signaling generates pattern through two distinct mechanisms.
- Interaction of Wnt-1 proteins with the binding protein BiP
- Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderm-inducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis.
- Lack of beta-catenin affects mouse development at gastrulation.
- Negative regulation of Armadillo, a Wingless effector in Drosophila.
- The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells
- Signaling activities of the Drosophila wingless gene are separately mutable and appear to be transduced at the cell surface.
- An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling
Cited by
- Fonction du facteur de choc thermique HSF2 dans les processus de prolifération, de survie et de différenciation au cours du développement du système nerveux central
- Molecular profiling in multiple myeloma
- Making mesoderm--upstream and downstream of Xbra.
- Cell determination and transdetermination in Drosophila imaginal discs.
- Corin, a Mosaic Transmembrane Serine Protease Encoded by a Novel cDNA from Human Heart*
- The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family.
- Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors
- Wnt signaling during BMP‐2 stimulation of mesenchymal chondrogenesis
- E- and N-cadherin distribution in developing and functional human teeth under normal and pathological conditions.
- Developmental biology: Colon construction
- Wnt-frizzled signaling in the induction and differentiation of the neural crest.
- A large scale screen for genes (3rd chromosome) related to Wingless signaling pathway
- Multiple functions for the cadherin/catenin complex during neuronal development.
- Connective Tissue Growth Factor (CTGF) Is Regulated by Wnt and Bone Morphogenetic Proteins Signaling in Osteoblast Differentiation of Mesenchymal Stem Cells*
- Dynamic expression of Wnt signaling‐related Dickkopf1, ‐2, and ‐3 mRNAs in the developing mouse tooth
- Formation and Plasticity of Neuromuscular Synaptic Connections
- The genetics of low-density lipoprotein receptor-related protein 5 in bone: a story of extremes.
- CBP/p300 are bimodal regulators of Wnt signaling
- Increased connexin 43 expression improves the migratory and proliferative ability of H9c2 cells by Wnt-3a overexpression.
- Signaling pathways and preimplantation development of mammalian embryos
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