The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase.
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Summary
It is shown that Akt and the Akt-related kinase AKT2 are activated by PDGF, and it is suggested that the AkT PH domain may be a mediator of PI 3-kinase signaling.
- Type
- article
- Published
- 1995-06-02
- Cited by
- 2,129
- References
- 30
- Access
- Open access
- OpenAlex
- https://openalex.org/W2004078164
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12000355
Keywords
Protein kinase B, Pleckstrin homology domain, AKT1, AKT2, Biology
References
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- Regulating 56 kinase
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- Binding of G protein beta gamma-subunits to pleckstrin homology domains.
- D-myo-inositol 1,4,5-trisphosphate inhibits binding of phospholipase C-delta 1 to bilayer membranes.
- Phosphatidylinositol-3-OH kinase direct target of Ras
- Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.
- AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation
- GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit
- AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.
- Protein modules and signalling networks
- A survey of expressed genes in Caenorhabditis elegans
- Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation.
- A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region.
- Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice.
- Dimerization of cell surface receptors in signal transduction
- Control of the Balb/c‐3T3 cell cycle by nutrients and serum factors: Analysis using platelet‐derived growth factor and platelet‐poor plasma
- Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase.
Cited by
- Survival factors and apoptosis.
- ON T CELL FATE DECISIONS: RETINOL, METABOLISM AND ITREG DIFFERENTIATION
- Akt Regulation of Adipogenesis: Implications for Skp2 Involvement
- Molecular biology of pancreatic carcinoma.
- Genetic modulation of hypoxia induced gene expression and angiogenesis: relevance to brain tumors.
- Cpk Is a Novel Class of Drosophila PtdIns 3-Kinase Containing a C2 Domain*
- Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase
- Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt
- Involvement of Phosphatidylinositol 3-Kinase in NFAT Activation in T Cells*
- Expression of a Constitutively Active Phosphatidylinositol 3-Kinase Induces Process Formation in Rat PC12 Cells
- Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
- The inhibition of cell signaling pathways by antitumor ether lipids.
- Akt, a Target of Phosphatidylinositol 3-Kinase, Inhibits Apoptosis in a Differentiating Neuronal Cell Line
- A Redox-triggered Ras-Effector Interaction
- Cyclin D1 Expression Mediated by Phosphatidylinositol 3-Kinase through mTOR-p70S6K-Independent Signaling in Growth Factor-Stimulated NIH 3T3 Fibroblasts
- Phosphoinositide kinases and the synthesis of polyphosphoinositides in higher plant cells.
- Activation of Akt is induced by heat shock and involved in suppression of heat-shock-induced apoptosis of NIH3T3 cells.
- Epidermal Growth Factor Receptor-dependent Control of Keratinocyte Survival and Bcl-xL Expression through a MEK-dependent Pathway*
- PKB/AKT: functional insights from genetic models
- A Distinct Class of Dominant Negative Ras Mutants
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