Mechanisms and consequences of activation of protein kinase B/Akt.
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Summary
Activated PKB/Akt provides a survival signal that protects cells from apoptosis induced by various stresses, and also mediates a number of metabolic effects of insulin.
- Type
- review
- Published
- 1998-04-01
- Cited by
- 1,387
- References
- 51
- OpenAlex
- https://openalex.org/W2046867705
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1683054
Keywords
Pleckstrin homology domain, Protein kinase B, AKT1, AKT2, Biology
References
- Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase
- Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt
- Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
- Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation.
- Insulin stimulates the kinase activity of RAC‐PK, a pleckstrin homology domain containing ser/thr kinase.
- Phosphatidylinositol-3-OH kinase direct target of Ras
- Mechanism of activation of protein kinase B by insulin and IGF‐1.
- Activation of phosphoinositide 3‐kinase by interaction with Ras and by point mutation.
- Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B.
- Akt Is a Direct Target of the Phosphatidylinositol 3-Kinase
- Molecular cloning of rat RAC protein kinase alpha and beta and their association with protein kinase C zeta.
- Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation*
- Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F.
- Interleukin 3-dependent survival by the Akt protein kinase.
- Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor.
- 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.
- A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region.
- High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity*
- The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase.
- GSK3: a SHAGGY frog story.
Cited by
- Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells.
- Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells.
- Insulin Signaling and Action in Fat Cells: Associations with Insulin Resistance and Type 2 Diabetes
- Kinase pathways in dominant and subordinate ovarian follicles during the first wave of follicular development in sheep.
- Abnormal T Cell Receptor Signal Transduction of CD4 Th Cells in X-Linked Lymphoproliferative Syndrome1
- Regulation of the PRL promoter by Akt through cAMP response element binding protein.
- A role for survivin in chemoresistance of endothelial cells mediated by VEGF
- Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer
- The Role of Asp-462 in Regulating Akt Activity*
- Pyrrolidine dithiocarbamate‐induced neuronal cell death is mediated by Akt, casein kinase 2, c‐Jun N‐terminal kinase, and IκB kinase in embryonic hippocampal progenitor cells
- Apoptosis: Akt is more than just a Bad kinase
- Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis
- Cell‐cycle regulation of T‐cell responses – novel approaches to the control of alloimmunity
- Lupeol modulates NF-κB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice
- Role of AKT/PKB signaling in fibroblast growth factor‐1 (FGF‐1)‐induced angiogenesis in the chicken chorioallantoic membrane (CAM)
- Protein tyrosine phosphatases: their role in insulin action and potential as drug targets.
- Inhibition of the phosphatidylinositol 3-kinase/Akt pathway by inositol pentakisphosphate results in antiangiogenic and antitumor effects.
- Regulation of Akt by arachidonic acid and phosphoinositide 3-kinase in angiotensin II-stimulated vascular smooth muscle cells.
- Phosphatidylserine induces apoptosis in adherent cells
- Integrin signaling in cancer.
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