The proteins encoded by c-akt and v-akt differ in post-translational modification, subcellular localization and oncogenic potential.
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Summary
To determine whether the differences in post-translational modification and subcellular distribution between c-akt and v-AKt translated into oncogenicity differences between the two proteins, retrovirus based constructs were used to express them both in the nontumorigenic rat T cell lymphoma line 5675 and found that neither was oncogenic.
- Type
- article
- Published
- 1993-07-01
- Cited by
- 168
- References
- 0
- OpenAlex
- https://openalex.org/W119017381
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25399013
Keywords
Protein kinase B, Biology, AKT1, Phosphorylation, Molecular biology
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