Phosphatidylinositol-3-OH kinase direct target of Ras
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Summary
In vivo, dominant negative Ras mutant N17 inhibits growth factor induced production of 3′ hosphorylated phosphoinositides in PC12 cells, and transfection of Ras, but not Raf, into COS cells results in a large elevation in the level of these lipids.
- Type
- article
- Published
- 1994-08-18
- Cited by
- 2,032
- References
- 36
- OpenAlex
- https://openalex.org/W1585517331
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26050169
Keywords
Phosphatidylinositol, Kinase, Cell biology, Effector, GTP'
References
- Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation.
- Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system.
- Divergent regulation of phosphatidylinositol 3-kinase P85 alpha and P85 beta isoforms upon T cell activation.
- Antibodies: A Laboratory Manual
- Expression and characterization of the Ha-ras p21 protein produced at high levels in the insect/baculovirus system.
- Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor
- The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytes
- Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types
- Agonist-induced association of the p21ras GTPase-activating protein with phosphatidylinositol 3-kinase.
- Implication of GAP in Ras-dependent transactivation of a polyoma enhancer sequence.
- ras p21 and GAP inhibit coupling of muscarinic receptors to atrial K+ channels.
- Plugging the GAPs.
- Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro
- Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases.
- Identification of the SH3 domain of GAP as an essential sequence for Ras-GAP-mediated signaling.
- Activation of the MAP kinase pathway by the protein kinase raf.
- Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling
- MAP kinase kinase kinase, MAP kinase kinase and MAP kinase.
- IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.
- Raf-1 activates MAP kinase-kinase
Cited by
- Mutations of the NF1 gene in children with juvenile myelomonocytic leukemia without clinical evidence of neurofibromatosis, type 1.
- Transformation and pp60v-src autophosphorylation correlate with SHC-GRB2 complex formation in rat and chicken cells expressing host-range and kinase-active, transformation-defective alleles of v-src.
- Thyrotropin-induced mitogenesis is Ras dependent but appears to bypass the Raf-dependent cytoplasmic kinase cascade
- Opportunities for pharmacological intervention in the ras pathway.
- Autophosphorylation of Activation Loop Tyrosines Regulates Signaling by the TRK Nerve Growth Factor Receptor*
- Involvement of Phosphatidylinositol 3-Kinase in NFAT Activation in T Cells*
- Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
- A Redox-triggered Ras-Effector Interaction
- Cyclin D1 Expression Mediated by Phosphatidylinositol 3-Kinase through mTOR-p70S6K-Independent Signaling in Growth Factor-Stimulated NIH 3T3 Fibroblasts
- Membrane-targeted Phosphatidylinositol 3-Kinase Mimics Insulin Actions and Induces a State of Cellular Insulin Resistance*
- Presence of up-stream and downstream components of a mitogen-activated protein kinase pathway in the PSD of the rat forebrain.
- Inhibition of basophil histamine release by tyrosine kinase and phosphatidylinositol 3-kinase inhibitors.
- PKB/AKT: functional insights from genetic models
- A Distinct Class of Dominant Negative Ras Mutants
- Activation of Ras/Erk Pathway by a Novel MET-interacting Protein RanBPM*
- Intracellular signals involved in the effects of insulin-like growth factors and neuregulins on myofibre formation.
- Inhibitor of apoptosis protein (IAP) survivin is upregulated by oncogenic c-H-Ras
- Involvement of the extracellular signal regulated kinase pathway in hydrocarbon-induced reactive oxygen species formation in human neutrophil granulocytes.
- K-Ras and H-Ras activation promote distinct consequences on endometrial cell survival.
- Phosphatidylinositol 3-Kinase Signaling Is Involved in Neurogenesis during Xenopus Embryonic Development*
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