Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice.
Explore this paper's citation graph
Summary
It is demonstrated that src is not required for general cell viability (possibly because of functional overlap with other tyrosine kinases related to src) and an essential role for src in bone formation is uncovered.
- Type
- article
- Published
- 1991-02-22
- Cited by
- 2,057
- References
- 46
- OpenAlex
- https://openalex.org/W2000170431
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:30794665
Keywords
Biology, Osteopetrosis, Proto-oncogene tyrosine-protein kinase Src, Null allele, Osteoclast
References
- Processing of p60v-src to its myristylated membrane-bound form
- Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses
- Alterations in pp60c-src accompany differentiation of neurons from rat embryo striatum
- Biological and biochemical properties of the c-src+ gene product overexpressed in chicken embryo fibroblasts
- Myristic acid, a rare fatty acid, is the lipid attached to the transforming protein of Rous sarcoma virus and its cellular homolog
- Retroviruses as probes for mammalian development: allocation of cells to the somatic and germ cell lineages.
- Spleen cells transmit osteopetrosis in mice
- Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity.
- Targeted homologous recombination at the endogenous adenine phosphoribosyltransferase locus in Chinese hamster cells.
- c-src gene product in developing rat brain is enriched in nerve growth cone membranes.
- Expression of c-src and c-abl in embryonal carcinoma cells and adult mouse tissues.
- Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter.
- Association between the PDGF receptor and members of the src family of tyrosine kinases.
- Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
- Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells.
- DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA
- Neuronal pp60c-src contains a six-amino acid insertion relative to its non-neuronal counterpart.
- Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines
- Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse.
- Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells
Cited by
- Development of osteoclasts from embryonic stem cells through a pathway that is c-fms but not c-kit dependent.
- Phosphorylation of the human estrogen receptor on tyrosine 537 in vivo and by src family tyrosine kinases in vitro.
- Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity
- Biochemistry of B lymphocyte activation.
- Thinking about genetic redundancy.
- Differentially load-regulated gene expression in mouse trabecular osteocytes
- Growth retardation and early death of β‐1, 4‐galactosyltransferase knockout mice with augmented proliferation and abnormal differentiation of epithelial cells
- Cyclic peptides as probes of the substrate binding site of the cytosolic tyrosine kinase, pp60c-src.
- Long-term room temperature storage of high-quality embryonic stem cell genomic DNA extracted with a simple and rapid procedure.
- PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase.
- Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation.
- Targeted disruption of the tyrosine phosphatase PTPα leads to constitutive downregulation of the kinases Src and Fyn
- The tyrosine phosphatase SHP-1 is a negative regulator of osteoclastogenesis and osteoclast resorbing activity: increased resorption and osteopenia in me(v)/me(v) mutant mice.
- Ubiquitin-mediated degradation of active Src tyrosine kinase.
- The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylation.
- Computational binding studies of human pp60c-src SH2 domain with a series of nonpeptide, phosphophenyl-containing ligands.
- Coordinate interactions of Csk, Src, and Syk kinases with αIIbβ3 initiate integrin signaling to the cytoskeleton
- U0126 and PD98059, Specific Inhibitors of MEK, Accelerate Differentiation of RAW264.7 Cells into Osteoclast-like Cells*
- Src kinase has a central role in in vitro cellular internalization of Staphylococcus aureus
- Integrin-mediated signaling in the regulation of osteoclast adhesion and activation.
Related papers
- Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus.
- Null alleles at two lactate dehydrogenase loci in rainbow trout are associated with decreased developmental stability
- CRISPR/Cas9-Mediated Insertion of loxP Sites in the Mouse Dock7 Gene Provides an Effective Alternative to Use of Targeted Embryonic Stem Cells
- Null and conditional semaphorin 3B alleles using a flexible puroΔtk loxP/FRT vector
- Conditional gene knockout using Cre recombinase.
- Spontaneous and carcinogen–induced tumorigenesis in p53–deficient mice
- Deletion of the NOT4 gene impairs hyphal development and pathogenicity in Candida albicans.
- Afraid of complications in gene targeting? Anxiety plays a role!
- A method for the generation of conditional gene repair mutations in mice.