Impairment of the ubiquitin-proteasome system by protein aggregation.

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Summary

It is reported that protein aggregation directly impaired the function of the ubiquitin-proteasome system, suggesting a potential mechanism linking protein aggregation to cellular disregulation and cell death.

Type
article
Published
2001-05-25
Cited by
2,084
References
14

Keywords

Proteasome, Ubiquitin, Cell biology, Proteolysis, Protein aggregation

References

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