The Effects of Aging on Proteasome Activity, Assembly, and Abundance in C. elegans
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Summary
In aging C. elegans, it is determined that proteasome activity increases with age to compensate for the decline in general proteostasis, and this increased activity is regulated by increasing proteasomal abundance, likely through the regulation of limiting subunits.
- Type
- article
- Published
- 2012-01-01
- Cited by
- 0
- References
- 102
- Access
- Open access
- OpenAlex
- https://openalex.org/W2108910980
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16609646
Keywords
Proteostasis, Proteasome, Biology, Cell biology, Proteolysis
References
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- The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.
- Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination
- 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila
- Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
- Multiubiquitin Chain Binding and Protein Degradation Are Mediated by Distinct Domains within the 26 S Proteasome Subunit Mcb1*
- Temporal Requirements of Insulin/IGF-1 Signaling for Proteotoxicity Protection
- Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry.
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- Identification, Purification, and Characterization of a PA700-dependent Activator of the Proteasome (*)
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