The ubiquitin-proteasome system: focus on the heart.
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Summary
Present knowledge about structure and function of the proteasome in the heart is summarized and the relevance of the UPS for cardiac diseases is discussed.
- Type
- review
- Published
- 2006-06-01
- Cited by
- 124
- References
- 89
- Access
- Open access
- OpenAlex
- https://openalex.org/W2131587773
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14046406
Keywords
Proteasome, Ubiquitin, Cell biology, Intracellular, Internalization
References
- A proteasome inhibitor prevents activation of NF‐kappa B and stabilizes a newly phosphorylated form of I kappa B‐alpha that is still bound to NF‐kappa B.
- Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
- Proteolytic Regulation of the Zinc Finger Transcription Factor YY1, a Repressor of Muscle-restricted Gene Expression*
- Mutation R120G in alphaB-crystallin, which is linked to a desmin-related myopathy, results in an irregular structure and defective chaperone-like function.
- Emerging roles of proteasomes in ischemia-reperfusion injury of organs.
- Pathologic alterations in hypertrophic and congestive cardiomyopathy of cats.
- The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation
- Isoforms of mammalian ubiquitin-activating enzyme.
- A missense mutation in the αB-crystallin chaperone gene causes a desmin-related myopathy
- Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
- Organization and sequence of human cardiac myosin binding protein C gene (MYBPC3) and identification of mutations predicted to produce truncated proteins in familial hypertrophic cardiomyopathy.
- Sepsis stimulates release of myofilaments in skeletal muscle by a calcium‐dependent mechanism
- Abundance and location of the small heat shock proteins HSP25 and alphaB-crystallin in rat and human heart.
- Clinical features and prognostic implications of familial hypertrophic cardiomyopathy related to the cardiac myosin-binding protein C gene.
- Gene expression profiling of oxidative stress on atrial fibrillation in humans
- Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I
- Novel splice donor site mutation in the cardiac myosin-binding protein-C gene in familial hypertrophic cardiomyopathy. Characterization Of cardiac transcript and protein.
- A proteasome inhibitor confers cardioprotection.
- Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product.
- Mechanisms of plasma membrane protein degradation: recycling proteins are degraded more rapidly than those confined to the cell surface.
Cited by
- New frontiers in heart hypertrophy during pregnancy.
- mTOR in Growth and Protection of Hypertrophying Myocardium
- Bortezomib-induced Dilated cardiomyopathy - Myth or Reality
- Mulibrey nanism : Clinical characteristics and pathophysiologic features of growth restriction, insulin resistance and tumour development
- Mulibrey nanism: Characterization of hypogonadism, infertility and tumors
- Role of ubiquitin-proteasome system (UPS) in left ventricular hypertrophy (LVH).
- Alterations of the ubiquitin-proteasome system in targeted cMyBP-C mice with hypertrophic cardiomyopathy
- Der Einfluss des Proteasominhibitors Bortezomib auf die kardiale Hypertrophie in der Dahl Salz-sensitiven Ratte
- The mammalian target of rapamycin modulates the immunoproteasome system in the heart.
- Proteasome Inhibitors : a novel therapy that blunt hyperglycemia-induced cardiac contractile dysfunction
- Investigation of molecular mechanisms regulating the expression of cMyBP-C mutants in familial hypertrophic cardiomyopathy
- 3D-QSAR studies of boron-containing dipeptides as proteasome inhibitors with CoMFA and CoMSIA methods.
- The Role of the Proteasome in Heart Disease
- Reversible Heart Failure after Bortezomib Treatment in a Patient with Multiple Myeloma
- Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion
- Ubiquitin-proteasome system and hereditary cardiomyopathies.
- Proteasome inhibition slightly improves cardiac function in mice with hypertrophic cardiomyopathy
- Cardiac proteasome dysfunction during cold ischemic storage and reperfusion in a murine heart transplantation model.
- Defective proteolytic systems in Mybpc3-targeted mice with cardiac hypertrophy
- Down-regulation of the De-ubiquitinating Enzyme Ubiquitin-specific Protease 2 Contributes to Tumor Necrosis Factor-α-induced Hepatocyte Survival*
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