Proteomic and oxidative stress analysis in human brain samples of Huntington disease.
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Summary
A proteomic analysis of human brain postmortem samples obtained from striatum and cortex of patients with HD compared to samples of age- and sex-matched controls indicates that oxidative stress and damage to specific macromolecules would participate in the disease progression.
- Type
- article
- Published
- 2008-09-01
- Cited by
- 295
- References
- 95
- Access
- Open access
- OpenAlex
- https://openalex.org/W426097930
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10662004
Keywords
Huntington's disease, Oxidative stress, Disease, Neuroscience, Biology
References
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- MRI evaluation of basal ganglia ferritin iron and neurotoxicity in Alzheimer's and Huntingon's disease.
- Glial Fibrillary Acidic Protein: GFAP-Thirty-One Years (1969–2000)
- Overexpression and abnormal modification of the stress proteins alpha B-crystallin and HSP27 in Alexander disease.
- Selenium and selenoproteins in the brain and brain diseases
- Carbonyl assays for determination of oxidatively modified proteins.
- Influence of Huntington's disease on the human and mouse proteome.
- Increased infarct size and exacerbated apoptosis in the glutathione peroxidase‐1 (Gpx‐1) knockout mouse brain in response to ischemia/reperfusion injury
- Wild-Type Huntingtin Protects from Apoptosis Upstream of Caspase-3
- Huntingtin inclusion bodies are iron‐dependent centers of oxidative events
- Oxidative stress during aging of stationary cultures of the yeast Saccharomyces cerevisiae.
- The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease
- The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.
- Mitochondrial Hsp60, Resistance to Oxidative Stress, and the Labile Iron Pool Are Closely Connected in Saccharomyces cerevisiae *
- Trinucleotide (CAG) repeat expansion in chromosomes of Spanish patients with Huntington's disease
- The kynurenine pathway of tryptophan degradation as a drug target.
- Cortical glucose metabolism in Huntington's disease
Cited by
- Redox Proteomics in Selected Neurodegenerative Disorders: From Its Infancy to Future Applications
- The choreography of neuroinflammation in Huntington’s disease
- Mitochondrial fragmentation in neuronal degeneration: Toward an understanding of HD striatal susceptibility.
- Network analysis of human post-mortem microarrays reveals novel genes, microRNAs, and mechanistic scenarios of potential importance in fighting huntington's disease
- Mitochondrial dysfunction, metabolic deficits, and increased oxidative stress in Huntington's disease.
- Alterações neurogliais em ratos expostos ao ácido ocadáico como modelo de demência
- The role of mitochondrial dysfunction in Huntington's disease: pathogenesis and its relation with striatal Rhes protein
- Rôle de la dysfonction mitochondriale dans deux maladies neurodégénératives, la Maladie de Huntington et la Maladie de Parkinson
- CHARACTERIZING THE FUNCTION OF HUNTINGTIN IN THE CELL STRESS RESPONSE AS A TARGET FOR DRUG DISCOVERY IN HUNTINGTON’S DISEASE
- Knowledge derivation and data mining strategies for probabilistic functional integrated networks
- Influence of intensive multifunctional neurorehabilitation on neuronal oxidative damage in patients with Huntington's disease.
- Glutathione in Cellular Redox Homeostasis: Association with the Excitatory Amino Acid Carrier 1 (EAAC1)
- Besides Huntington's disease, does brain-type creatine kinase play a role in other forms of hearing impairment resulting from a common pathological cause?
- Analysis of Oxidative Damage by Gene‐Specific Quantitative PCR
- Lymphocytic Mitochondrial Aconitase Activity is Reduced in Alzheimer's Disease and Mild Cognitive Impairment
- Metabolism in HD - Still a relevant mechanism?
- β-cell dysfunction in Huntington's disease
- Protein carbonylation: proteomics, specificity and relevance to aging.
- Selenium and selenoprotein function in brain disorders
- NUB1 suppression of Huntington toxicity: mechanistic insights
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