FOXM1, a typical proliferation-associated transcription factor
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Summary
This review summarizes the current knowledge on FOXM1, in particular its two different transactivation mechanisms, the regulation of its transcriptional activity by proliferation versus anti-proliferation signals and its function in normal cell cycle progression and tumorigenesis.
- Type
- review
- Published
- 2007-12-01
- Cited by
- 337
- References
- 95
- OpenAlex
- https://openalex.org/W1987986416
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19721737
Keywords
Transactivation, FOXM1, Transcription factor, Promoter, Carcinogenesis
References
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- Hyaluronan Fragments Induce Endothelial Cell Differentiation in a CD44- and CXCL1/GRO1-dependent Manner*boxs
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- Distinctive molecular profiles of high-grade and low-grade gliomas based on oligonucleotide microarray analysis.
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- Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope.
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- Mitotic misregulation and human aging.
- FoxM1 dances with mitosis
- Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process
- Molecular Analysis of a Novel Winged Helix Protein, WIN
- Identification of a chemical inhibitor of the oncogenic transcription factor forkhead box M1.
- Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment
- Transcription factor FOXM1c is repressed by RB and activated by cyclin D1/Cdk4
Cited by
- The transcription factor FOXM1 (Forkhead box M1): proliferation-specific expression, transcription factor function, target genes, mouse models, and normal biological roles.
- Dissecting the telomere-independent pathways underlying human cellular senescence
- Polo-like Kinase 1-mediated Phosphorylation of Forkhead Box Protein M1b Antagonizes Its SUMOylation and Facilitates Its Mitotic Function*
- FOXM1 (Forkhead box M1) in tumorigenesis: overexpression in human cancer, implication in tumorigenesis, oncogenic functions, tumor-suppressive properties, and target of anticancer therapy.
- The Utilization of Mouse Models to Study Gene Functions: The Role of Foxn3 and Chd2 in Murine Development and Cancer
- The Effects of 17- Beta Estradiol on G-Protein Inwardly Rectifying Potassium Channels (GIRKs) in Breast Cancer
- Transcriptomic changes induced by mycophenolic acid in gastric cancer cells.
- Induction of forkhead box M1 (FoxM1) by EGF through ERK signaling pathway promotes trophoblast cell invasion
- Localisation et fonction de CHK2 en mitose
- Strategies to identify novel therapeutic targets for oesophageal adenocarcinoma
- Systems level investigation of the genetic basis of bovinemuscle growth and development
- RETRACTED ARTICLE: SUMO-specific protease 6 promotes gastric cancer cell growth via deSUMOylation of FoxM1
- Evolution of the Chordate Regeneration Blastema: Differential Gene Expression and Conserved Role of Notch Signaling During Siphon Regeneration in the Ascidian Ciona
- Transcriptional Control of Mitosis: Deregulation and Cancer
- Prognostic Value of FOXM1 in Patients with Malignant Solid Tumor: A Meta-Analysis and System Review
- FOXM1b, which is present at elevated levels in cancer cells, has a greater transforming potential than FOXM1c
- BIOLOGY OF FOXM1 AND ITS EMERGING ROLE IN CANCER THERAPY
- Delineation of biological and molecular mechanisms underlying the diverse anticancer activities of mycophenolic acid.
- FOXM1 binds directly to non-consensus sequences in the human genome
- Silibinin-induced glioma cell apoptosis by PI3K-mediated but Akt-independent downregulation of FoxM1 expression.
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