IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
Explore this paper's citation graph
Summary
Results indicate that the IGF-1 receptor may be a central regulator of mammalian lifespan, and shows greater resistance to oxidative stress.
- Type
- article
- Published
- 2003-01-09
- Cited by
- 2,092
- References
- 36
- Access
- Open access
- OpenAlex
- https://openalex.org/W1985425785
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4421807
Keywords
Insulin-like growth factor 1 receptor, Biology, Drosophila melanogaster, Insulin receptor, Endocrinology
References
- Let sleeping dogs lie?
- Chromatin structure analysis by ligation-mediated and terminal transferase-mediated polymerase chain reaction.
- FLP Recombinase-Mediated Induction of Cu/Zn-Superoxide Dismutase Transgene Expression Can Extend the Life Span of Adult Drosophila melanogaster Flies
- Genetic pathways that regulate ageing in model organisms
- Lifespan and incidence of cancer and other diseases in selected long-lived inbred mice and their F 1 hybrids.
- HDA1 and HDA3 Are Components of a Yeast Histone Deacetylase (HDA) Complex*
- Insulin/IGF signalling and ageing: seeing the bigger picture.
- ATP-Dependent histone octamer mobilization and histone deacetylation mediated by the Mi-2 chromatin remodeling complex.
- Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r).
- Longevity: Extending the lifespan of long-lived mice
- Mutations prolong life in flies; implications for aging in mammals.
- Low body temperature in long-lived Ames dwarf mice at rest and during stress.
- Spontaneous Testicular Teratomas in an Inbred Strain of Mice.
- Dietary Restriction in Long-Lived Dwarf Flies
- Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.
- Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein
- A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function
- daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.
- Experimental IGF-I receptor deficiency generates a sexually dimorphic pattern of organ-specific growth deficits in mice, affecting fat tissue in particular.
- Longevity and gross pathology at death in 22 inbred mouse strains.
Cited by
- Insulin-Like Growth Factor-1 Physiology: Lessons from Mouse Models
- Dynamics of liver GH/IGF axis and selected stress markers in juvenile gilthead sea bream (Sparus aurata) exposed to acute confinement: differential stress response of growth hormone receptors.
- Genetic variation and human longevity.
- The molecular mechanisms of life history alterations in a rotifer: a novel approach in population dynamics.
- Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21‐dependent pathway
- Implication du BDNF dans l'étiopathogenèse et le traitement des troubles anxio-dépressifs : aspects précliniques.
- Vascular cell senescence and vascular aging.
- Mutations in Chemosensory Cilia Cause Resistance to Paraquat in Nematode Caenorhabditis elegans*
- Autophagy and aging--importance of amino acid levels.
- IGFs and aging: is there a rationale for hormone replacement therapy?
- The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
- INSECT OLFACTORY RECEPTORS: CONTRIBUTIONS OF MOLECULAR BIOLOGY TO CHEMICAL ECOLOGY
- Genetics of aging: implications for drug discovery and development.
- Hepatocyte proliferation during liver regeneration is impaired in mice with liver‐specific IGF‐1R knockout
- Do large dogs die young?
- Association of Insulin-Like Growth Factor-1 Receptor Polymorphism in Dementia
- The lipid peroxidation end‐product 4‐HNE induces COX‐2 expression through p38MAPK activation in 3T3‐L1 adipose cell
- Management of growth hormone deficiency in adults.
- Higher circulating levels of IGF-1 are associated with longer leukocyte telomere length in healthy subjects.
- Dermal fibroblasts from long-lived Ames dwarf mice maintain their in vivo resistance to mitochondrial generated reactive oxygen species (ROS)
Related papers
- Controlled dimerization of insulin-like growth factor-1 and insulin receptors reveals shared and distinct activities of holo and hybrid receptors
- Minireview: nuclear insulin and insulin-like growth factor-1 receptors: a novel paradigm in signal transduction.
- Insulin and Insulin-like Growth Factor-1 Receptors Act as Ligand-specific Amplitude Modulators of a Common Pathway Regulating Gene Transcription*
- Role of the insulin receptor in IGF-system signaling and biology.
- Classifying the adverse mitogenic mode of action of insulin analogues using a novel mechanism-based genetically engineered human breast cancer cell panel
- Insulin-like growth factor-2 (IGF-2); insulin-like growth factor-1 receptor (IGF1R; CD221)
- Functional Association between the Insulin Receptor and the Transmembrane Protein-tyrosine Phosphatase LAR in Intact Cells*
- Interaction of Insulin Receptor Substrate 3 with Insulin Receptor, Insulin Receptor-related Receptor, Insulin-like Growth Factor-1 Receptor, and Downstream Signaling Proteins*
- Protein kinase activity of the insulin receptor from muscle