Controlled dimerization of insulin-like growth factor-1 and insulin receptors reveals shared and distinct activities of holo and hybrid receptors
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Summary
The findings suggest that, when expressed and activated in mammary epithelial cells, HybR acts in a manner similar to IGF1R and support further investigation of the role of HyBR in breast cancer.
- Type
- article
- Published
- 2018-01-12
- Cited by
- 13
- References
- 23
- Access
- Open access
- OpenAlex
- https://openalex.org/W2783307588
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3933014
Keywords
Insulin-like growth factor 1 receptor, Insulin receptor, Receptor, Insulin-like growth factor, Cell biology
References
- Pleiotropic effects of FGFR1 on cell proliferation, survival, and migration in a 3D mammary epithelial cell model
- Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation.
- Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease.
- The Type 1 Insulin-Like Growth Factor Receptor Pathway
- Distribution of insulin/insulin-like growth factor-I hybrid receptors in human tissues.
- Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions.
- Specific insulin/IGF1 hybrid receptor activation assay reveals IGF1 as a more potent ligand than insulin
- Insulin and IGFs in Obesity-Related Breast Cancer
- How IGF-1 activates its receptor
- Microarray analysis and identification of novel molecules involved in insulin-like growth factor-1 receptor signaling and gene expression.
- Controlled activation of ErbB1/ErbB2 heterodimers promote invasion of three-dimensional organized epithelia in an ErbB1-dependent manner: implications for progression of ErbB2-overexpressing tumors.
- Increased expression of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of noninsulin-dependent diabetes mellitus subjects.
- Controlled Dimerization of ErbB Receptors Provides Evidence for Differential Signaling by Homo- and Heterodimers
- Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors.
- Multiple Signaling Pathways of the Insulin-Like Growth Factor 1 Receptor in Protection from Apoptosis
- Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling.
- The role of the insulin-like growth factor-1 system in breast cancer
- Monitoring the Activation State of Insulin/Insulin-Like Growth Factor-1 Hybrid Receptors Using Bioluminescence Resonance Energy Transfer
- Distinct roles of fibroblast growth factor receptor 1 and 2 in regulating cell survival and epithelial-mesenchymal transition.
- Global Cancer Incidence and Mortality Rates and Trends—An Update
Cited by
- FKBP Ligands—Where We Are and Where to Go?
- Paracrine Factors Released by Osteoblasts Provide Strong Platelet Engraftment Properties
- Insulin and insulin-like growth factors act as renal cell cancer intratumoral regulators
- Targeting the IGF-Axis for Cancer Therapy: Development and Validation of an IGF-Trap as a Potential Drug
- Lessons Learned from Targeting IGF-I Receptor in Thyroid-Associated Ophthalmopathy
- Postnatal Catch-Up Growth Programs Telomere Dynamics and Glucose Intolerance in Low Birth Weight Mice
- Unraveling the IGF System Interactome in Sarcomas Exploits Novel Therapeutic Options
- Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression
- Structural Models of Viral Insulin-like Peptides and their Analogs
- HER2-driven breast cancer suppression by the JNK signaling pathway
- Extracellular Interactors of the IGF System: Impact on Cancer Hallmarks and Therapeutic Approaches
- IGF1R/ARRB1 Mediated Regulation of ERK and cAMP Pathways in Response to Aβ Unfolds Novel Therapeutic Avenue in Alzheimer’s Disease
- Molecular Mechanisms of Endocrine Resistance
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