Minireview: nuclear insulin and insulin-like growth factor-1 receptors: a novel paradigm in signal transduction.
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Summary
The ability of InsR and IGF1R to function as transcription factors, although poorly understood, constitutes a new paradigm in signal transduction and may have a major basic and translational impact on the fields of metabolism, diabetes, and cancer.
- Type
- review
- Published
- 2013-03-18
- Cited by
- 81
- References
- 42
- Access
- Open access
- OpenAlex
- https://openalex.org/W2041064076
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:35320542
Keywords
Insulin-like growth factor 1 receptor, Insulin receptor, Signal transduction, Biology, Autophosphorylation
References
- Critical nodes in signalling pathways: insights into insulin action
- The Nuclear Epidermal Growth Factor Receptor Signaling Network and its Role in Cancer
- Nuclear translocation of the insulin receptor. A possible mediator of insulin's long term effects.
- Nerve growth factor receptors in chromatin of melanoma cells, proliferating melanocytes, and colorectal carcinoma cells in vitro.
- Insulin Receptor Isoform A, a Newly Recognized, High-Affinity Insulin-Like Growth Factor II Receptor in Fetal and Cancer Cells
- RETRACTED: Identification of Insulin-Like Growth Factor-I Receptor (IGF-IR) Gene Promoter-Binding Proteins in Estrogen Receptor (ER)-Positive and ER-Depleted Breast Cancer Cells
- The Functional Crosstalk between HER2 Tyrosine Kinase and TGF-β Signaling in Breast Cancer Malignancy
- SUMOylation Mediates the Nuclear Translocation and Signaling of the IGF-1 Receptor
- The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinoma
- P01-13 Mechanisms behind nuclear translocation of the IGF-1R
- The decline and fall of the IGF‐I receptor
- Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease.
- Insulin binding sites on rat liver nuclear membranes: Biochemical and immunofluorescent studies
- Nuclear IGF1R is a transcriptional co‐activator of LEF1/TCF
- Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: a predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas.
- Increased abundance of insulin/IGF-I hybrid receptors in adipose tissue from NIDDM patients.
- Cooperation of Nuclear Fibroblast Growth Factor Receptor 1 and Nurr1 Offers New Interactive Mechanism in Postmitotic Development of Mesencephalic Dopaminergic Neurons*
- Intracellular binding sites for insulin are immunologically distinct from those on the plasma membrane
- Mechanisms of Disease: using genetically altered mice to study concepts of type 2 diabetes
- Binding of insulin to isolated nuclei.
Cited by
- Role of dysregulated expression of leptin and leptin receptors in colorectal carcinogenesis
- Combined treatment with platelet‐rich plasma and insulin favours chondrogenic and osteogenic differentiation of human adipose‐derived stem cells in three‐dimensional collagen scaffolds
- Effects of Chinese Fructus Mume formula and its separated prescription extract on insulin resistance in type 2 diabetic rats
- Neurotrophic uncoupling of IGF-1 in Alzheimer’s disease: translation into early diagnosis and involvement of lifestyle risk factors
- IGFBP2 POTENTIATES EGFR-STAT3 SIGNALING IN GLIOMA
- Pathogenic mechanisms behind dysregulated angiogenesis with focus on HIF and IGF-I signaling
- Differentiation of osteoblasts to osteocytes in 3D type I collagen gels - a novel tool to study osteocyte responses to mechanical loading
- Disrupted TSH Receptor Expression in Female Mouse Lung Fibroblasts Alters Subcellular IGF-1 Receptor Distribution.
- Detection of Phosphorylated Insulin Receptor in Colorectal Adenoma and Adenocarcinoma: Implications for Prognosis and Clinical Outcome
- Venus Kinase Receptors: Prospects in Signaling and Biological Functions of These Invertebrate Kinases
- Transcriptional and epigenetic control of IGF1R gene expression: implications in metabolism and cancer.
- The ins and outs of fibroblast growth factor receptor signalling.
- IGF binding proteins in cancer: mechanistic and clinical insights
- Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation
- The emerging role of insulin-like growth factors in testis development and function
- IGFBP2 potentiates nuclear EGFR-STAT3 signaling
- Targeting the insulin-like growth factor pathway in hepatocellular carcinoma.
- Minimal tags for rapid dual-color live-cell labeling and super-resolution microscopy.
- Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors
- Insulin growth factor binding proteins as therapeutic targets in type 2 diabetes
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