Mutations prolong life in flies; implications for aging in mammals.

Keywords

Longevity, Biology, Insulin receptor, Drosophila melanogaster, Insulin

References

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• Free radical defenses in the liver and kidney of human growth hormone transgenic mice: possible mechanisms of early mortality.Steven Hauck, A. Bartke — 2001
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Cited by

• Autophagy and aging--importance of amino acid levels.Jordi Sala — 2004
• Enhanced glycogenesis is involved in cellular senescence via GSK3/GS modulationYonghak Seo, Hyun‐Jung Jung, Hyun‐Taek Shin — 2008
• The dwarf mutation decreases high dose insulin responses in skeletal muscle, the opposite of effects in liver.Fernando P. Dominici, Danila P. Argentino, Andrzej Bartke — 2003
• IGF-1 receptor regulates lifespan and resistance to oxidative stress in miceMartin Holzenberger, Joëlle Dupont, Bertrand Ducos — 2003
• A polymorphic CA repeat in the IGF‐I gene is associated with gender‐specific differences in body height, but has no effect on the secular trend in body heightIngrid Rietveld, J. A. M. J. L. Janssen, Elisabeth F. C. van Rossum — 2004
• Evolving dispersal and age at deathCalvin Dytham, Justin M. J. Travis — 2006
• The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically.E. Bergamini, Gabriella Cavallini, A. Donati — 2003
• Effect of dietary restriction during development on the level of expression of longevity-associated genes in Drosophila melanogasterAlexander Vaiserman, Alexander Koliada, O. G. Zabuga — 2014
• Glycogen Synthase Kinase 3 Inactivation Induces Cell Senescence through Sterol Regulatory Element Binding Protein 1-Mediated Lipogenesis in Chang CellsYou‐Mie Kim, Insun Song, Yonghak Seo — 2013
• Body size, energy metabolism and lifespanJohn R. Speakman — 2005
• A low-fat, whole-food vegan diet, as well as other strategies that down-regulate IGF-I activity, may slow the human aging process.Mark F. McCarty — 2003
• Consequences of growth hormone (GH) overexpression and GH resistance.Andrzej Bartke, V. Chandrashekar, Brianna Bailey — 2002
• Animal Models for the IGF-1 Signal System in LongevityInseok Kwak — 2012
• Effects of long-term caloric restriction on glucose homeostasis and on the first steps of the insulin signaling system in skeletal muscle of normal and Ames dwarf (Prop1df/Prop1df) mice.Danila P. Argentino, Fernando P. Dominici, Marina C. Muñoz — 2005
• IGF-1 signaling and aging.Martin Holzenberger, Laurent Kappeler, Carlos De Magalhaes Filho — 2004
• The role of insulin and IGF-1 signaling in longevityMaša Katić, C. Ronald Kahn — 2005
• Shuttling between species for pathways of lifespan regulation: a central role for the vitellogenin gene family?Bernd W. Brandt, Bas J. Zwaan, Marian Beekman — 2005
• The GH/IGF-I axis and longevity.Martin Holzenberger — 2004
• The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseases.E. Bergamini, Gabriella Cavallini, A. Donati — 2004
• An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations.K. C. Kregel, Hannah J. Zhang — 2007

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