DNA damage, aging, and cancer.
Explore this paper's citation graph
Summary
Evidence that cancer and diseases of aging are two sides of the DNAdamage problem is presented, followed by an account of the derailment of genome guardian mechanisms in cancer and of how this cancerspecific phenomenon can be exploited for treatment.
- Type
- review
- Published
- 2009-12-10
- Cited by
- 2,181
- References
- 77
- Access
- Open access
- OpenAlex
- https://openalex.org/W1982602899
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205115506
Keywords
DNA damage, Medicine, DNA repair, Cancer, DNA
References
- Lamin A/C, laminopathies and premature ageing.
- Premature aging in mice activates a systemic metabolic response involving autophagy induction.
- Genetic instability syndromes with progeroid features
- DNA Repair and Mutagenesis
- Transcription-coupled repair of oxidative DNA damage in human cells: mechanisms and consequences.
- Aging, tumor suppression and cancer: high wire-act!
- A temperature-sensitive disorder in basal transcription and DNA repair in humans
- Single-strand break repair and genetic disease
- Caloric restriction delays disease onset and mortality in rhesus monkeys
- DNA damage signalling guards against activated oncogenes and tumour progression
- Role of insulin-like signalling in Drosophila lifespan.
- Molecular mechanisms of mammalian global genome nucleotide excision repair.
- Transcription-coupled repair and premature ageing.
- Mutational spectra of human cancer
- Subpathways of nucleotide excision repair and their regulation
- A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
- Chromatin Recruitment of DNA repair proteins: Lessons from the Fanconi Anemia and Double Strand Break Repair Pathways
- The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis
- Mutator pathways unleashed by epigenetic silencing in human cancer.
- The DNA damage response pathways: at the crossroad of protein modifications
Cited by
- Human variation databases
- The dynamic interplay in chromatin remodeling factors polycomb and trithorax proteins in response to DNA damage
- RNA modifications by oxidation: a novel disease mechanism?
- Resilient and resourceful: genome maintenance strategies in hematopoietic stem cells
- Mutation signatures of carcinogen exposure: genome-wide detection and new opportunities for cancer prevention
- Aging Biology in the Kidney.
- Crystal structure of human PCNA in complex with the PIP box of DVC1.
- Trial Watch: Targeting ATM–CHK2 and ATR–CHK1 pathways for anticancer therapy
- Discover the network mechanisms underlying the connections between aging and age-related diseases
- Anti-Müllerian Hormone Trajectories Are Associated With Cardiovascular Disease in Women: Results From the Doetinchem Cohort Study
- DNA Damage and Repair Biomarkers of Immunotherapy Response
- DNA repair goes hip-hop: SMARCA and CHD chromatin remodellers join the break dance
- Genome instability syndromes caused by impaired DNA repair and aberrant DNA damage responses
- Gallic acid, a common dietary phenolic protects against high fat diet induced DNA damage
- DNA damage and protein oxidation associated with ageing correlate with cognitive dysfunction in a Malaysian population
- A limited number of double-strand DNA breaks is sufficient to delay cell cycle progression
- Cyclin B1/CDK1-regulated mitochondrial bioenergetics in cell cycle progression and tumor resistance
- Keeping ribosomal DNA intact: a repeating challenge
- In vitro cytogenetic assays: chromosomal aberrations and micronucleus tests.
- Study of impact of reduced Sox4 expression levels in homeostasis, cancer and ageing
Related papers
- The role of progesterone-induced blocking factor (PIBF) in invasion of primary ovarian tumour cells
- DNA damage repair and cardiovascular diseases.
- Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress
- Interplay between DNA repair and inflammation, and the link to cancer
- DNA damage repair and response proteins as targets for cancer therapy.
- Cytotoxicity and mutagenicity of endogenous DNA base lesions as potential cause of human aging.
- Activation of DNA damage response signaling in mammalian cells by ionizing radiation
- USP7S-dependent inactivation of Mule regulates DNA damage signalling and repair
- New Insights into the Link Between DNA Damage and Apoptosis