Aging, tumor suppression and cancer: high wire-act!
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Summary
Recent data are described that support the idea that both senescence and apoptosis may indeed be the double-edged swords predicted by the evolutionary hypothesis of antagonistic pleiotropy-protecting organisms from cancer early in life but promoting aging phenotypes, including late life cancer, in older organisms.
- Type
- article
- Published
- 2004-08-15
- Cited by
- 172
- References
- 112
- Access
- Open access
- OpenAlex
- https://openalex.org/W1562572266
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10987824
Keywords
Multicellular organism, Senescence, Biology, Pleiotropy, Somatic cell
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Cited by
- The transcription factor FOXM1 (Forkhead box M1): proliferation-specific expression, transcription factor function, target genes, mouse models, and normal biological roles.
- Autophagy in axonal degeneration in glaucomatous optic neuropathy.
- FOXM1 (Forkhead box M1) in tumorigenesis: overexpression in human cancer, implication in tumorigenesis, oncogenic functions, tumor-suppressive properties, and target of anticancer therapy.
- Effect of host age on tumor growth rate in rodents.
- Establishing a role for specific nutrients in Drosophila dietary restriction
- Roles of Apoptosis and Cellular Senescence in Cancer and Aging.
- Stress-induced Premature Promotes Prostate Cancer Growth and Metastasis through Alteration of Microenvironment
- Twist as a new prognostic marker in hematological malignancies
- Impact of aging on the biology of breast cancer.
- The genetics of ageing: insight from genome‐wide approaches in invertebrate model organisms
- Loss of intestinal nuclei and intestinal integrity in aging C. elegans
- Aging Process Modulates Nonlinear Dynamics in Liver Cell Metabolism*
- P53-Rb signaling pathway is involved in tubular cell senescence in renal ischemia/reperfusion injury.
- Regulation of Leukocyte Infiltration into Ovarian Cancer by Tumour-Stroma Interactions: A Microarray View of Cancer Microenvironment
- BIOMARKERS AND THE GENETICS OF EARLY NEOPLASTIC LESIONS
- Triterpenes from the Protium heptaphyllum resin – chemical composition and cytotoxicity
- SUMO, the three Rs and cancer.
- Actividad de la -galactosidasa como marcador de senescencia en cultivos primarios del epitelio superficial del ovario.
- Heme Deficiency Is Associated with Senescence and Causes Suppression of N-Methyl-d-aspartate Receptor Subunits Expression in Primary Cortical Neurons
- Applications of Stochastic Processes to Cancer Research
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