Crystal structure of human PCNA in complex with the PIP box of DVC1.
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Summary
The crystal structure of human PCNA in complex with a peptide ((321)SNSHQNVLSNYFPRVS(336)) derived from human DVC1 that contains a unique YF type PIP box is reported, offering new insights into the determinants of PIPbox for PCNA binding.
- Type
- dissertation
- Published
- 2016-05-27
- Cited by
- 18
- References
- 34
- OpenAlex
- https://openalex.org/W27084448
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20195618
Keywords
Vanadium, Chemistry, Nuclear chemistry, Physical chemistry, Inorganic chemistry
References
- Proliferating cell nuclear antigen structure and interactions: too many partners for one dancer?
- Structural and Functional Insight into Proliferating Cell Nuclear Antigen.
- Repair of topoisomerase I-mediated DNA damage.
- DNA–protein crosslink repair
- DNA damage, aging, and cancer.
- DVC1 (C1orf124) is a DNA damage–targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks
- Effects of Uracil Incorporation, DNA Mismatches, and Abasic Sites on Cleavage and Religation Activities of Mammalian Topoisomerase I*
- Identification of Small Molecule Proliferating Cell Nuclear Antigen (PCNA) Inhibitor That Disrupts Interactions with PIP-box Proteins and Inhibits DNA Replication*
- Characterization of human Spartan/C1orf124, an ubiquitin-PCNA interacting regulator of DNA damage tolerance
- DNA repair mechanisms in dividing and non-dividing cells
- The puzzle of PCNA's many partners
- DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage
- Regulation of PCNA–protein interactions for genome stability
- DNA-protein crosslink repair: proteases as DNA repair enzymes.
- A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen.
- Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-delta p66 subunit and flap endonuclease-1.
- Spartan/C1orf124 is important to prevent UV-induced mutagenesis
- Ubiquitin-dependent Destruction of Topoisomerase I Is Stimulated by the Antitumor Drug Camptothecin*
- A DNA-dependent protease involved in DNA-protein crosslink repair.
- Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design.
Cited by
- PCNA dependent cellular activities tolerate dramatic perturbations in PCNA client interactions
- Behaviour of intrinsically disordered proteins in protein–protein complexes with an emphasis on fuzziness
- Structure insights into the molecular mechanism of the interaction between UHRF2 and PCNA.
- Structural and Functional Studies of the β2-Sliding Clamp from Pathogenic Bacteria
- Structure of proliferating cell nuclear antigen (PCNA) bound to an APIM peptide reveals the universality of PCNA interaction.
- Maneuvers on PCNA Rings during DNA Replication and Repair
- The p12 subunit of human polymerase δ uses an atypical PIP box for molecular recognition of proliferating cell nuclear antigen (PCNA)
- ATXR5/6 Forms Alternative Protein Complexes with PCNA and the Nucleosome Core Particle.
- The PCNA interaction motifs revisited: thinking outside the PIP-box
- Targeting PCNA with Peptide Mimetics for Therapeutic Purposes
- Human PCNA Structure, Function, and Interactions
- Structure of PCNA in complex with DNMT1 PIP box reveals the basis for the molecular mechanism of the interaction.
- Mechanisms and Regulation of DNA-Protein Crosslink Repair During DNA Replication by SPRTN Protease
- Prot2Prot: a deep learning model for rapid, photorealistic macromolecular visualization
- Molecular insight into the PCNA-binding mode of FBH1
- Targeting the "Undruggable": Small-Molecule Inhibitors of Proliferating Cell Nuclear Antigen (PCNA) in the Spotlight in Cancer Therapy.
- The dual ubiquitin binding mode of SPRTN secures rapid spatiotemporal proteolysis of DNA–protein crosslinks
- Crystal structure of human PCNA in complex with DNMT1 PIP box motif.
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