Creation of human tumour cells with defined genetic elements
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Summary
It is shown that the ectopic expression of the telomerase catalytic subunit (hTERT) in combination with two oncogenes results in direct tumorigenic conversion of normal human epithelial and fibroblast cells.
- Type
- article
- Published
- 1999-07-29
- Cited by
- 2,465
- References
- 51
- OpenAlex
- https://openalex.org/W1545398558
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2377425
Keywords
Telomerase, Telomerase reverse transcriptase, Biology, Ectopic expression, Phenotype
References
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- Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
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- Activated v-myc and v-ras oncogenes do not transform normal human lymphocytes
- Recombinant retroviruses encoding simian virus 40 large T antigen and polyomavirus large and middle T antigens
- A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae.
- Telomere structure and telomerase expression during mouse development and tumorigenesis.
- Malignant transformation of human fibroblasts caused by expression of a transfected T24 HRAS oncogene.
- An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast.
- Effect of oncogene expression on telomerase activation and telomere length in human endothelial, fibroblast and prostate epithelial cells.
- Correlation of patterns of anchorage-independent growth with in vivo behavior of cells from a murine fibrosarcoma.
- Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
- Heterologous modules for efficient and versatile PCR‐based gene targeting in Schizosaccharomyces pombe
- The rad21 Gene Product of Schizosaccharomyces pombe Is a Nuclear, Cell Cycle-regulated Phosphoprotein (*)
- Specific association of human telomerase activity with immortal cells and cancer.
- Holding chromatids together to ensure they go their separate ways
Cited by
- La protéine de stress Hsp27 / HspB1, une cible de choix en thérapie anti-cancéreuse
- Development of an shRNA screen to identify mediators of cellular senescence in human breast epithelial cells
- Modelling chromosome missegregation in tumour evolution
- Telomerase Promoter-Driven Cancer Cell Suicide
- The incidence of acute promyelocytic leukemia appears constant over most of a human lifespan, implying only one rate limiting mutation
- The Myc/Max/Mad network and the transcriptional control of cell behavior.
- Conditional immortalization of freshly isolated human mammary fibroblasts and endothelial cells.
- Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes.
- Talking tumours: histories from sequences
- Glucose regulates protein catabolism in ras-transformed fibroblasts through a lysosomal-dependent proteolytic pathway.
- Differentiation Genes: Are They Primary Targets for Human Carcinogenesis?
- Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes.
- Reduced expression of insulin-like growth factor binding protein-3 and its promoter hypermethylation in human hepatocellular carcinoma.
- Telomere maintenance and cancer ? look, no telomerase
- Defined human cellular systems in the study of glioma development.
- Oncogenic signaling pathways and deregulated target genes.
- Farnesyltransferase inhibitor SCH66336 induces rapid phosphorylation of eukaryotic translation elongation factor 2 in head and neck squamous cell carcinoma cells.
- Establishing cell-based reporter systems for the analysis of hTERT expression.
- The Chromosomal Basis of Cancer
- Identification and characterization of tumorigenic liver cancer stem/progenitor cells.
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- Immortalized cells with no detectable telomerase activity. A review.
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- Telomerase inhibition in a mouse cell line with long telomeres leads to rapid telomerase reactivation.