Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
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Summary
Endoplasmic reticulum stress and related signaling networks, (adipo)cytokines, and innate immunity are emerging as central pathways that regulate key features of NASH.
- Type
- review
- Published
- 2010-11-01
- Cited by
- 2,447
- References
- 117
- Access
- Open access
- OpenAlex
- https://openalex.org/W1967972402
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:34330016
Keywords
Nonalcoholic fatty liver disease, Inflammation, Nonalcoholic steatohepatitis, Medicine, Disease
References
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- Homozygosity for the patatin‐like phospholipase‐3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease
- Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitis
- Free fatty acids promote hepatic lipotoxicity by stimulating TNF‐α expression via a lysosomal pathway
- Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease.
- Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice.
- Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1
- A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance
- Toll-like receptor activation of XBP1 regulates innate immune responses in macrophages
Cited by
- Bias in macrophage activation pattern influences non-alcoholic steatohepatitis (NASH) in mice.
- A Critical Appraisal of Advances in Pediatric Nonalcoholic Fatty Liver Disease
- Clinicopathological characteristics and metabolic profiles of non-alcoholic fatty liver disease in Indian patients with normal body mass index: Do they differ from obese or overweight non-alcoholic fatty liver disease?
- Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH
- Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice
- Obesity-mediated association between exposure to brominated trihalomethanes and type II diabetes mellitus: an exploratory analysis.
- Adipose Tissue Dysfunction and Altered Systemic Amino Acid Metabolism Are Associated with Non-Alcoholic Fatty Liver Disease
- Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease
- TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity
- Siphonaxanthin, a Carotenoid From Green Algae, Inhibits Lipogenesis in Hepatocytes via the Suppression of Liver X Receptor α Activity.
- Ethanol extract of Allium fistulosum inhibits development of non-alcoholic fatty liver disease
- Animal models of NAFLD from a hepatologist's point of view.
- Association of low skeletal muscle mass with advanced liver fibrosis in patients with non‐alcoholic fatty liver disease
- Toll-like receptors in liver disease.
- De la stéatohépatite non alcoolique au carcinome hépatocellulaire : mécanismes physiopathologiques
- Linking Nonalcoholic Fatty Liver Disease to Hepatocellular Carcinoma: From Bedside to Bench and Back
- Rôle du Liver X Receptor dans la régulation transcriptionnelle de la lipogenèse
- Investigating the Metabolic and Pathophysiological Ramifications of Elevated Dietary Cholesterol and Macronutrient Manipulation in Guinea Pigs (Cavia porcellus) with Non-alcoholic Fatty Liver Disease (NAFLD)
- Obésité et maladie du foie gras non alcoolique
- Chronic inflammation aggravates metabolic disorders of hepatic fatty acids in high-fat diet-induced obese mice
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