Investigating the Metabolic and Pathophysiological Ramifications of Elevated Dietary Cholesterol and Macronutrient Manipulation in Guinea Pigs (Cavia porcellus) with Non-alcoholic Fatty Liver Disease (NAFLD)
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Summary
Examining the impact of a dietary cholesterol challenge on NAFLD progression in phenotypically normal guinea pigs, an animal that more closely approximates humans in terms of hepatic cholesterol handling and metabolism than other commonly utilized animal models, found modest hepatic steatosis.
- Type
- article
- Published
- 2013-01-01
- Cited by
- 0
- References
- 61
- Access
- Open access
- OpenAlex
- https://openalex.org/W189292090
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:68488505
Keywords
Cavia, Fatty liver, Pathophysiology, Medicine, Guinea pig
References
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- Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
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- A human-type nonalcoholic steatohepatitis model with advanced fibrosis in rabbits.
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- Is the slippery slope from steatosis to steatohepatitis paved with triglyceride or cholesterol?
- DisseCCTing Phospholipid Function in Lipid Droplet Dynamics
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