Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance
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Summary
It is shown that C3H/HeJ mice, which have a loss-of-function mutation in TLR4, are protected against the development of diet-induced obesity and a potential target for the therapy of these highly prevalent medical conditions.
- Type
- article
- Published
- 2007-08-01
- Cited by
- 837
- References
- 51
- Access
- Open access
- OpenAlex
- https://openalex.org/W17519423
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12846469
Keywords
Political science
References
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Cited by
- Role of immune mediators in metabolic syndrome and atherosclerosis
- Maternal Obesity, Inflammation, and Fetal Skeletal Muscle Development1
- Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet
- Western diet enhances hepatic inflammation in mice exposed to cecal ligation and puncture
- Cannabinoid signalling regulates inflammation and energy balance: the importance of the brain-gut axis.
- Frequency of Firmicutes and Bacteroidetes in gut microbiota in obese and normal weight Egyptian children and adults
- Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications.
- Citrus flavonoid naringenin inhibits TLR2 expression in adipocytes.
- The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling
- The Phagocyte, Metchnikoff, and the Foundation of Immunology
- Short-Term Versus Long-Term Effects of Adipocyte Toll-Like Receptor 4 Activation on Insulin Resistance in Male Mice
- Green tea extract prevents obesity in male mice by alleviating gut dysbiosis in association with improved intestinal barrier function that limits endotoxin translocation and adipose inflammation.
- Neuroinflammation in Overnutrition-induced Diseases
- Adipose tissue inflammation in obesity and during surgery induced-weight loss : emerging paracrine dialogue between macrophages and lymphocytes
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- Short-term feeding effects of high-fat diet on hippocampal neuroinflammation: Differences among C57BL/6J, C3H/HeN, and C3H/HeJ mice
- Mapping the diverse functions of dietary fatty acids via target gene regulation
- IMMUNE MODULATION OF METABOLISM: THE ROLE OF MACROPHAGES, NKTCELLS AND DENDRITIC CELLS IN THE DEVELOPMENT OF THE METABOLICDISTURBANCES OF OBESITY
- Obesity and adipose tissue expansion in Ossabaw swine
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