Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice.
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Summary
A review of recent advances in the field of nonalcoholic fatty liver disease discusses recent advances and suggests that modulating important enzymes in fatty acid synthesis in liver may be key for the treatment of NAFLD.
- Type
- review
- Published
- 2008-03-03
- Cited by
- 1,231
- References
- 105
- Access
- Open access
- OpenAlex
- https://openalex.org/W1969734540
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25683463
Keywords
Steatosis, Insulin resistance, Nonalcoholic fatty liver disease, Fatty liver, Cirrhosis
References
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- Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
- Rat ATP citrate-lyase. Molecular cloning and sequence analysis of a full-length cDNA and mRNA abundance as a function of diet, organ, and age.
- Regulation of the expression of the L-type pyruvate kinase gene in adult rat hepatocytes in primary culture.
- Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis.
- Mitochondrial Reactive Oxygen Species Signal Hepatocyte Steatosis by Regulating the Phosphatidylinositol 3-Kinase Cell Survival Pathway*
- "New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis.
- Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor alpha (PPARalpha)-independent pathway.
- The Physiology of Obese-Hyperglycemic Mice [ob/ob Mice]
- The subcellular localization of acetyl-CoA carboxylase 2.
- The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance.
- Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease.
- The Role of SREBP-1c in Nutritional Regulation of Lipogenic Enzyme Gene Expression*
- Modulation of sterol regulatory element binding proteins (SREBPs) as potential treatments for non-alcoholic fatty liver disease (NAFLD).
- Fatty acid elongases in mammals: their regulation and roles in metabolism.
- Glucose as a regulator of eukaryotic gene transcription.
- Sweet dreams for LXR.
- Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice.
Cited by
- Some inflammatory cytokine levels, iron metabolism and oxidan stress markers in subjects with nonalcoholic steatohepatitis.
- Impact of dietary dairy polar lipids on lipid metabolism of mice fed a high-fat diet.
- S 50131 and S 51434, two novel small molecule glucokinase activators, lack chronic efficacy despite potent acute antihyperglycaemic activity in diabetic mice
- Oleanolic Acid Diminishes Liquid Fructose-Induced Fatty Liver in Rats: Role of Modulation of Hepatic Sterol Regulatory Element-Binding Protein-1c-Mediated Expression of Genes Responsible for De Novo Fatty Acid Synthesis
- Monoacylglycerol O-acyltransferase 1 is regulated by peroxisome proliferator-activated receptor γ in human hepatocytes and increases lipid accumulation.
- Nonalcoholic fatty liver disease
- De Novo Lipogenesis Products and Endogenous Lipokines
- Silymarin prevents lipid accumulation in the liver of rats with type 2 diabetes via sirtuin1 and SREBP-1c
- Subchronic cadmium exposure upregulates the mRNA level of genes associated to hepatic lipid metabolism in adult female CD1 mice
- Lipid accumulation responses in the liver of Rana nigromaculata induced by perfluorooctanoic acid (PFOA).
- Mechanisms of Glucocorticoid-Induced Insulin Resistance
- Proposed mechanisms of action of serum triglyceride lowering by plant sterols and stanols
- Identification des éléments clefs du métabolisme des lipides et de leurs régulateurs
- Fetal and Neonatal Exposure to Nicotine Augments Hepatic Fatty Acid Synthesis in Rat Offspring Long-Term
- Sensitivity analysis in systems biology modelling and its application to a multi-scale model of blood glucose homeostasis
- The Impact of Dietary Methionine Restriction on Biomarkers of Metabolic Health
- Metabolic Significance of Fatty Acid Elongation
- REGULATION OF ATP BINDING CASSETTE TRANSPORTER A1 AND G1 EXPRESSION BY FATTY ACIDS
- Rôle du Liver X Receptor dans la régulation transcriptionnelle de la lipogenèse
- The contribution of vascular adhesion protein-1 to glucose and lipid homeostasis in the liver
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