Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice.
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Summary
F Fas in adipocytes contributes to adipose tissue inflammation, hepatic steatosis, and insulin resistance induced by obesity and may constitute a potential therapeutic target for the treatment of insulin resistance and type 2 diabetes.
- Type
- article
- Published
- 2010-01-04
- Cited by
- 166
- References
- 59
- Access
- Open access
- OpenAlex
- https://openalex.org/W1986656589
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5966645
Keywords
Adipose tissue, Insulin resistance, Internal medicine, Endocrinology, Steatosis
References
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- Indinavir uncovers different contributions of GLUT4 and GLUT1 towards glucose uptake in muscle and fat cells and tissues
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- A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance
- Caspase 1-independent IL-1β release and inflammation induced by the apoptosis inducer Fas ligand
- Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice.
- Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle
- Improved glucose tolerance in mice receiving intraperitoneal transplantation of normal fat tissue
- Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes.
- Ceramides in insulin resistance and lipotoxicity.
- Interleukin-6 and insulin sensitivity: friend or foe?
- Abnormal lipid and glucose metabolism in obesity: implications for nonalcoholic fatty liver disease.
- Fas ligand induces cell-autonomous NF-kappaB activation and interleukin-8 production by a mechanism distinct from that of tumor necrosis factor-alpha.
- Fas Ligand-induced Proinflammatory Transcriptional Responses in Reconstructed Human Epidermis
- Basal lipolysis, not the degree of insulin resistance, differentiates large from small isolated adipocytes in high-fat fed mice
Cited by
- Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet
- Systems biology of adipose tissue metabolism: regulation of growth, signaling and inflammation
- Immuno-Modulator Metallo-Peptide Reduces Inflammatory State in Obese Zucker Fa/Fa Rats
- Visceral fat and metabolic inflammation: the portal theory revisited
- Proapoptotic and survival signaling in the neuroretina at early stages of diabetic retinopathy
- ESSENTIAL ROLE OF PROTEIN TYROSINE PHOSPHATASE 1B IN OBESITY-INDUCED INFLAMMATION AND PERIPHERAL INSULIN RESISTANCE DURING AGING
- The PGE2 EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice.
- Identification of a novel 11β-HSD1 inhibitor from a high-throughput screen of natural product extracts.
- IRF5 deficiency ameliorates lupus but promotes atherosclerosis and metabolic dysfunction in a mouse model of lupus-associated atherosclerosis
- Novel Biomarkers For Non-Alcoholic Fatty Liver Disease and Associated Symptoms
- Are Obesity-Related Insulin Resistance and Type 2 Diabetes Autoimmune Diseases?
- Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
- Novel Insights into the Pathophysiology of Nonalcoholic Fatty Liver Disease
- Interleukin-1β Regulates Fat-Liver Crosstalk in Obesity by Auto-Paracrine Modulation of Adipose Tissue Inflammation and Expandability
- Obesity, Inflammation and Liver Cancer
- Organic consequences of ileal transposition in rats with diet-induced obesity
- Obestatin regulates adipocyte function and protects against diet‐induced insulin resistance and inflammation
- TNF‐related apoptosis‐inducing ligand promotes human preadipocyte proliferation via ERK1/2 activation
- TRAIL (TNF-related apoptosis-inducing ligand) regulates adipocyte metabolism by caspase-mediated cleavage of PPARgamma
- Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications
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