Role of sphingosine kinase 1 and sphingosine‐1‐phosphate in CD40 signaling and IgE class switching
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Summary
It is found that ligation of CD40 activates and translocates SphK1 to the plasma membrane, leading to generation of S1P, which is important for CD40‐mediated B cell activation and regulation of humoral responses and suggest that targeting SphK 1 might be a useful therapeutic approach to control antigen‐specific IgE production.
- Type
- article
- Published
- 2014-07-01
- Cited by
- 11
- References
- 60
- Access
- Open access
- OpenAlex
- https://openalex.org/W2029757123
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26056430
Keywords
Sphingosine-1-phosphate, Sphingosine, Sphingosine kinase, Sphingosine kinase 1, Immunoglobulin E
References
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- The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis.
- Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone
- S1P3 confers differential S1P migration by autoreactive and non-autoreactive immature B cells and is required for normal B cell development
- Glutamate signaling through the Kainate Receptor Enhances Human Immunoglobulin Production
- SKI-II, an inhibitor of sphingosine kinase, ameliorates antigen-induced bronchial smooth muscle hyperresponsiveness, but not airway inflammation, in mice.
- Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signals.
- CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells
- Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate
- The multifaceted roles of TRAFs in the regulation of B-cell function
- A role for sphingosine kinase 1 in dextran sulfate sodium‐induced colitis
- BCR ligation antagonizes the IL-21 enhancement of anti-CD40/IL-4 plasma cell differentiation and IgE production found in low density human B cell cultures.
- Effect of cell density on in vitro mouse immunoglobulin E production
- The sphingosine 1-phosphate receptor S1P2 maintains germinal center B cell homeostasis and promotes niche confinement
- A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent mouse model of allergic asthma
- Molecular mechanism and function of CD40/CD40L engagement in the immune system
- A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.
- Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM.
Cited by
- Transient receptor potential channel 1 maintains adherens junction plasticity by suppressing sphingosine kinase 1 expression to induce endothelial hyperpermeability
- Corticotrophin-releasing factor participates in S1PR3-dependent cPLA2 expression and cell motility in vascular smooth muscle cells.
- Orchestration of membrane receptor signaling by membrane lipids.
- In Vivo Imaging of Immune Cells in Peyer's Patches.
- Sphingolipids and their enigmatic role in asthma
- Sphingosine kinase 1 activation by estrogen receptor α36 contributes to tamoxifen resistance in breast cancer
- CD40 Enhances Sphingolipids in Orbital Fibroblasts: Potential Role of Sphingosine-1-Phosphate in Inflammatory T-Cell Migration in Graves' Orbitopathy.
- Sphingolipids and the link between alcohol and cancer
- Molecular cloning of duck CD40 and its immune function research
- Known and potential molecules associated with altered B cell development leading to predominantly antibody deficiencies
- Allergenic protein-induced type I hypersensitivity models: a review
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