Role of sphingolipids in arachidonic acid metabolism.
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Summary
The role of sphingolipids in the regulation of cPLA₂α and COX-2 is explored, which is a novel class of bioactive lipids that play key roles in theregulation of several cellular processes including growth, differentiation, inflammatory responses, and apoptosis.
- Type
- review
- Published
- 2014-03-20
- Cited by
- 46
- References
- 32
- Access
- Open access
- OpenAlex
- https://openalex.org/W1969745934
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23587655
Keywords
Sphingolipid, Ceramide, Sphingomyelin, Arachidonic acid, Lipid signaling
References
- Galpha12 specifically regulates COX-2 induction by sphingosine 1-phosphate. Role for JNK-dependent ubiquitination and degradation of IkappaBalpha.
- Apoptotic Cell-Derived Sphingosine-1-Phosphate Promotes HuR-Dependent Cyclooxygenase-2 mRNA Stabilization and Protein Expression1
- Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators.
- Principles of bioactive lipid signalling: lessons from sphingolipids
- Modulation of the activity of cytosolic phospholipase A2α (cPLA2α) by cellular sphingolipids and inhibition of cPLA2α by sphingomyelin[S]
- C2-di-ethyl-ceramide-1-phosphate as an inhibitor of group IVA cytosolic phospholipase A2.
- Ceramide induces serotonin release from RBL-2H3 mast cells through calcium mediated activation of phospholipase A2.
- The ceramide‐1‐phosphate analogue PCERA‐1 modulates tumour necrosis factor‐α and interleukin‐10 production in macrophages via the cAMP–PKA–CREB pathway in a GTP‐dependent manner
- Targeting the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway in Disease: Review of Sphingosine Kinase Inhibitors
- Contrary effects of sphingosine-1-phosphate on expression of α-smooth muscle actin in transforming growth factor β1-stimulated lung fibroblasts.
- Ceramide 1-Phosphate Is Required for the Translocation of Group IVA Cytosolic Phospholipase A2 and Prostaglandin Synthesis*
- Ceramide binds to the CaLB domain of cytosolic phospholipase A2 and facilitates its membrane docking and arachidonic acid release
- Newly synthetic ceramide-1-phosphate analogs; their uptake, intracellular localization, and roles as an inhibitor of cytosolic phospholipase A(2)α and inducer of cell toxicity.
- Ceramide-1-phosphate Binds Group IVA Cytosolic Phospholipase a2 via a Novel Site in the C2 Domain*
- Lactosylceramide Interacts with and Activates Cytosolic Phospholipase A2α*
- Effects of ceramide, ceramidase inhibition and expression of ceramide kinase on cytosolic phospholipase A2alpha; additional role of ceramide-1-phosphate in phosphorylation and Ca2+ signaling.
- The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors.
- Ceramide-1-phosphate activates cytosolic phospholipase A2alpha directly and by PKC pathway.
- Ceramide 1-Phosphate Acts as a Positive Allosteric Activator of Group IVA Cytosolic Phospholipase A2α and Enhances the Interaction of the Enzyme with Phosphatidylcholine*
- Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina.
Cited by
- The plasma metabolic profiling of chronic acephate exposure in rats via an ultra-performance liquid chromatography-mass spectrometry based metabonomic method.
- Trafficking of Acetyl‐C16‐Ceramide‐NBD with Long‐Term Stability and No Cytotoxicity into the Golgi Complex
- Role of Ceramide from Glycosphingolipids and Its Metabolites in Immunological and Inflammatory Responses in Humans
- Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy.
- Roles of lipid-modulating enzymes diacylglycerol kinase and cyclooxygenase under pathophysiological conditions
- Effect of pulsed electromagnetic field treatment on programmed resolution of inflammation pathway markers in human cells in culture
- Comprehensive Proteomic and Metabolomic Signatures of Nontypeable Haemophilus influenzae-Induced Acute Otitis Media Reveal Bacterial Aerobic Respiration in an Immunosuppressed Environment*
- Fostering Inflammatory Bowel Disease: Sphingolipid Strategies to Join Forces
- Cellular function and signaling pathways of vascular smooth muscle cells modulated by sphingosine 1-phosphate.
- Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism
- Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease
- KLINISCHE CHEMIE UND LABORATORIUMSMEDIZIN
- Lactosylceramide‐Induced Phosphorylation Signaling to Group IVA Phospholipase A2 via Reactive Oxygen Species in Tumor Necrosis Factor‐α‐Treated Cells
- The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer
- Oral ibuprofen differentially affects plasma and sweat lipid mediator profiles in healthy adult males
- Cancer Prevention and Therapy with Polyphenols: Sphingolipid-Mediated Mechanisms
- Non-Invasive Profiling of Sweat-derived Lipid Mediators for Cutaneous Research
- Translocation and activation of sphingosine kinase 1 by ceramide‐1‐phosphate
- Lipidomics as a diagnostic tool of the metabolic and physiological state of managed whales: A correlation study of systemic metabolism.
- Inflammatory response and its relation to sphingolipid metabolism proteins: Chaperones as potential indirect anti-inflammatory agents.
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