Effective cytotoxicity against human leukemias and chemotherapy-resistant leukemia cell lines by N-N-dimethylsphingosine.
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Summary
Leukemia samples showed a similar sensitivity to DMS as that of the cell lines, firstly demonstrating PKC-independent sphingolipid activity against fresh human tumor specimens, indicating DMS-based chemotherapy may improve leukemia treatment.
- Type
- article
- Published
- 2002-03-01
- Cited by
- 32
- References
- 57
- OpenAlex
- https://openalex.org/W1969284241
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19043665
Keywords
HL60, Leukemia, K562 cells, Cytotoxicity, Chemotherapy
References
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- Ceramide toxicity and metabolism differ in wild-type and multidrug-resistant cancer cells.
- Ceramide: an intracellular signal for apoptosis.
Cited by
- Sphingosine-dependent apoptosis: a unified concept based on multiple mechanisms operating in concert.
- Therapeutic potential of targeting SK1 in human cancers.
- Efeito antitumoral e antiangiogênico dos extratos bruto e supercríticoo de Bidens pilosa Linné e Casearia sylvestris Swartz
- Los esfingolípidos en la muerte y proliferación celular
- Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators.
- FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia.
- Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting shingosine kinase-1
- Sphingolipid players in the leukemia arena.
- Sphingosine kinase-1 – a potential therapeutic target in cancer
- Sphingosine 1-phosphate as a therapeutic agent
- In vitro anti‐leukaemia activity of sphingosine kinase inhibitor
- MRP- and BCL-2-mediated drug resistance in human SCLC: effects of apoptotic sphingolipids in vitro.
- A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.
- Sphingosine kinase 1 overexpression is regulated by signaling through PI3K, AKT2, and mTOR in imatinib-resistant chronic myeloid leukemia cells.
- Apoptotic Sphingolipid Ceramide in Cancer Therapy
- Enzymes of sphingosine metabolism as potential pharmacological targets for therapeutic intervention in cancer.
- Role of Sphingosine Kinase 2 in Cell Migration toward Epidermal Growth Factor*
- Sphingosine kinase 1 is involved in dibutyryl cyclic AMP-induced granulocytic differentiation through the upregulation of extracellular signal-regulated kinase, but not p38 MAP kinase, in HL60 cells.
- Interleukin-1β maintains an apoptosis-resistant phenotype in the blast cells of acute myeloid leukaemia via multiple pathways
- Sphingosine kinase inhibitors in the apoptosis of leukaemia cells.
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