Positive Modulation of IL-12 Signaling by Sphingosine Kinase 2 Associating with the IL-12 Receptor β1 Cytoplasmic Region 1
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Summary
Results suggest that sphingosine kinase 2 (SPHK2) associates with the IL-12Rβ1 cytoplasmic region and probably plays a role in modulating IL- 12 signaling.
- Type
- article
- Published
- 2003-08-01
- Cited by
- 76
- References
- 51
- Access
- Open access
- OpenAlex
- https://openalex.org/W1881674564
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25958744
Keywords
Cell biology, Janus kinase 2, Janus kinase, MAP kinase kinase kinase, Biology
References
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- Tyrphostin B42 inhibits IL-12-induced tyrosine phosphorylation and activation of Janus kinase-2 and prevents experimental allergic encephalomyelitis.
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- Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor.
- Sphingosine 1-Phosphate and Isoform-specific Activation of Phosphoinositide 3-Kinase β
- Cloning and characterization of a mouse IL-12 receptor-beta component.
- Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130.
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- TNF-α-Induced Sphingosine 1-Phosphate Inhibits Apoptosis Through a Phosphatidylinositol 3-Kinase/Akt Pathway in Human Hepatocytes1
- Impairment of STAT Activation by IL-12 in a Patient with Atypical Mycobacterial and Staphylococcal Infections1
- Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
- IL-12 acts directly on DC to promote nuclear localization of NF-kappaB and primes DC for IL-12 production.
- Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function.
- Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes.
- Sphingosine 1-phosphate signalling in mammalian cells.
Cited by
- New insights into the regulation of vascular permeability.
- INTRACELLULAR TARGETS OF SPHINGOSINE-1-PHOSPHATE
- IL-27 Induces Th1 Differentiation via p38 MAPK/T-bet- and Intercellular Adhesion Molecule-1/LFA-1/ERK1/2-Dependent Pathways1
- Extracellular and Intracellular Actions of Sphingosine-1-Phosphate
- Interleukin‐2 inhibits polarization to T helper type 1 cells and prevents mouse acute graft‐versus‐host disease through up‐regulating suppressors of cytokine signalling‐3 expression of naive CD4+ T cells
- Antiproliferative Activity of IL-27 on Melanoma1
- Engagement of TLR3, TLR7, and NKG2D Regulate IFN-γ Secretion but Not NKG2D-Mediated Cytotoxicity by Human NK Cells Stimulated with Suboptimal Doses of IL-121
- STAT3 Is Indispensable to IL-27-Mediated Cell Proliferation but Not to IL-27-Induced Th1 Differentiation and Suppression of Proinflammatory Cytokine Production1
- An Indispensable Role for STAT1 in IL-27-Induced T-bet Expression but Not Proliferation of Naive CD4+ T Cells1
- SEC14L2 enables pan-genotype HCV replication in cell culture
- Antiangiogenic and Antitumor Activities of IL-271
- Sphingosine Kinase 1 Is a Negative Regulator of CD4+ Th1 Cells
- Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators.
- Adjuvant Activities of Novel Cytokines, Interleukin-23 (IL-23) and IL-27, for Induction of Hepatitis C Virus-Specific Cytotoxic T Lymphocytes in HLA-A*0201 Transgenic Mice
- Adult cardiac fibroblasts null for sphingosine kinase-1 exhibit growth dysregulation and an enhanced proinflammatory response.
- IgE-dependent Activation of Sphingosine Kinases 1 and 2 and Secretion of Sphingosine 1-Phosphate Requires Fyn Kinase and Contributes to Mast Cell Responses*
- The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen.
- Asp177 in C4 domain of mouse sphingosine kinase 1a is important for the sphingosine recognition
- Sphingosine-1-phosphate synthesis and functions in mast cells
- Sphingosine kinase signalling in immune cells: potential as novel therapeutic targets.
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