Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy

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Summary

Let-7 induced autophagy in the brain to eliminate protein aggregates, establishing its physiological relevance for in vivo autophagy modulation and peripheral delivery of let-7 anti-miR repressed autophagy in muscle and white fat, suggesting that let-7 autophagy regulation extends beyond CNS.

Type
dissertation
Published
2014-10-07
Cited by
85
References
44
Access
Open access

Keywords

CMOS, Amplifier, RF power amplifier, Electrical engineering, Electronic engineering

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