Cell cycle regulation by the nutrient-sensing mammalian target of rapamycin (mTOR) pathway.
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Summary
How the nutrient-sensing mTOR-signaling cascade molecularly integrates nutritional and mitogenic/anti-apoptotic cues to accurately coordinate cell growth and cell cycle is reviewed.
- Type
- review
- Published
- 2014-01-01
- Cited by
- 119
- References
- 148
- OpenAlex
- https://openalex.org/W119015983
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:34001661
Keywords
mTORC2, PI3K/AKT/mTOR pathway, mTORC1, RPTOR, Cell cycle
References
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- Regulation of Ribosomal S6 Kinase 2 by Mammalian Target of Rapamycin*
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- mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).
Cited by
- ERK-mediated autophagy promotes inactivated Sendai virus (HVJ-E)-induced apoptosis in HeLa cells in an Atg3-dependent manner
- Age-related Changes in the Proteostasis Network in the Brain of the Naked Mole-Rat: Implications Promoting Healthy Longevity
- Mathematical modeling of normal and cancer prostate signaling pathways
- Dramatic antitumor effects of the dual mTORC1 and mTORC2 inhibitor AZD2014 in hepatocellular carcinoma.
- Linking diet to acne metabolomics, inflammation, and comedogenesis: an update
- Pharmacology of the cell/matrix form of adhesion.
- Pharmacological and Morphological Evidence of AMPK-Mediated Energy Sensing in the Lower Brain Stem Ependymocytes to Control Reproduction in Female Rodents.
- mTOR: A Potential Therapeutic Target in Osteoarthritis?
- The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration.
- Repurposing of nitroxoline as a potential anticancer agent against human prostate cancer – a crucial role on AMPK/mTOR signaling pathway and the interplay with Chk2 activation
- Relationship between mammalian target of rapamycin and autophagy in lipopolysaccharide-induced lung injury.
- Selective vulnerability of cancer cells by inhibition of Ca2+ transfer from endoplasmic reticulum to mitochondria
- Anticancer Activities of the Methanolic Extract from Lemon Leaves in Human Breast Cancer Stem Cells
- 17β-estradiol activates mTOR in chondrocytes by AKT-dependent and AKT-independent signaling pathways.
- Akt and β-catenin contribute to TMZ resistance and EMT of MGMT negative malignant glioma cell line.
- VPS34 regulates TSC1/TSC2 heterodimer to mediate RheB and mTORC1/S6K1 activation and cellular transformation
- Lipid Sensing by Mammalian Target of Rapamycin
- Autophagy is the key process in the re‐establishment of the epitheloid phenotype during mesenchymal‐epithelial transition (MET)
- Dissect the Dynamic Molecular Circuits of Cell Cycle Control through Network Evolution Model
- Down-regulation of islet amyloid polypeptide expression induces death of human annulus fibrosus cells via mitochondrial and death receptor pathways.
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