Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages.
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Summary
It is demonstrated that autophagic pathways can overcome the trafficking block imposed by M. tuberculosis, which is a hormonally, developmentally, and immunologically regulated process, represents an underapp appreciated innate defense mechanism for control of intracellular pathogens.
- Type
- article
- Published
- 2004-12-17
- Cited by
- 2,321
- References
- 61
- Access
- Open access
- OpenAlex
- https://openalex.org/W2012451546
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16651183
Keywords
Autophagy, Phagosome, Biology, Cell biology, Phagolysosome
References
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Cited by
- Estudio del rol de la vía de PD-1 sobre la respuesta inmune de células Nk y de los mecanismos inmunológicos inducidos por las células Th9 frente a la infección por M. tuberculosis
- Vitamin D, Vitamin D Receptor, and Macroautophagy in Inflammation and Infection
- Examining the regulation of virulence factors in Francisella tularensis
- Autophagy in immunity against intracellular bacteria.
- Mycobacterium tuberculosis Subverts Innate Immunity to Evade Specific Effectors1
- Bacillus Calmette-Guerin mechanism of action: the role of immunity, apoptosis, necrosis and autophagy.
- Impaired Macrophage Function Underscores Susceptibility to Salmonella in Mice Lacking Irgm1 (LRG-47)1
- Avoiding death by autophagy: Interactions of Listeria monocytogenes with the macrophage autophagy system
- Monitoring Autophagy during Mycobacterium tuberculosis Infection
- NADPH oxidases contribute to autophagy regulation
- Autophagy is an inflammation-related defensive mechanism against disease.
- Role of autophagy and autophagy genes in inflammatory bowel disease.
- Eradication of intracellular Francisella tularensis in THP-1 human macrophages with a novel autophagy inducing agent
- IL-32 Is a Host Protective Cytokine against Mycobacterium tuberculosis in Differentiated THP-1 Human Macrophages
- Rôle du stress du réticulum endoplasmique et de l’autophagie dans la régulation des réponses immune et angiogénique activées par des stress ischémiques et inflammatoires dans l’épithélium rénal humain
- Gut Microbiota, Probiotics and Inflammatory Bowel Disease
- Autophagy favors Brucella melitensis survival in infected macrophages
- Internalized gap junctions are degraded by autophagy
- Function of GRIM-19, a Mitochondrial Respiratory Chain Complex I Protein, in Innate Immunity*
- Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program.
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