Tumour-educated macrophages promote tumour progression and metastasis
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Summary
Macrophages are educated by the tumour microenvironment, so that they adopt a trophic role that facilitates angiogenesis, matrix breakdown and tumour-cell motility — all of which are elements of the metastatic process.
- Type
- review
- Published
- 2004-01-01
- Cited by
- 3,464
- References
- 100
- OpenAlex
- https://openalex.org/W1480357432
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:37256912
Keywords
Angiogenesis, Metastasis, Cancer research, Macrophage, Motility
References
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- Macrophage-tumour cell associations in breast cancer
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- Targeting the prostate tumor microenvironment and vasculature : the role of castration, tumor-associated macrophages and pigment epithelium-derived factor
- Cell Adhesion Biophysics on Dynamic Polymer Constructs
- An orthotopic metastatic prostate cancer model in SCID mice via grafting of a transplantable human prostate tumor line
- Effector memory T cells, early metastasis, and survival in colorectal cancer.
- Chemokines, chemokine receptors, and cancer metastasis
- Target validation using RNA interference in solid tumors.
- Immunomodulatory and anti-tumor activities of native and heat denatured Abrus agglutinin.
- Immune-refractory cancers and their little helpers--an extended role for immunetolerogenic MHC molecules HLA-G and HLA-E?
- Neutrophils in antibody-based immunotherapy of cancer
- Synergystic induction of HIF-1α transcriptional activity by hypoxia and lipopolysaccharide in macrophages
- Angiostatic immune reaction in colorectal carcinoma: Impact on survival and perspectives for antiangiogenic therapy
- Flt-1 signaling in macrophages promotes glioma growth in vivo.
- Optical imaging of the peri-tumoral inflammatory response in breast cancer
- Hypoxia Potentiates Glioma-Mediated Immunosuppression
- Harnessing dendritic cells to improve allogeneic hematopoietic cell transplantation outcome.
- A Large Cohort Study Reveals the Association of Elevated Peripheral Blood Lymphocyte-to-Monocyte Ratio with Favorable Prognosis in Nasopharyngeal Carcinoma
- Tumor-Derived Interleukin-1 Promotes Lymphangiogenesis and Lymph Node Metastasis through M2-Type Macrophages
- Host Cxcr2-dependent regulation of mammary tumor growth and metastasis
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