Macrophages can recognize and kill tumor cells bearing the membrane isoform of macrophage colony-stimulating factor.
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Summary
It is indicated that mM-CSF provides the necessary binding and triggering molecules through which macrophages can initiate direct tumor cell cytotoxicity.
- Type
- article
- Published
- 1996-06-15
- Cited by
- 72
- References
- 57
- Access
- Open access
- OpenAlex
- https://openalex.org/W174188130
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24395278
Keywords
Transfection, Macrophage colony-stimulating factor, Cytotoxicity, Molecular biology, Macrophage
References
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- Association of colorectal tumor epithelium expressing HLA-D/DR with CD8-positive T-cells and mononuclear phagocytes.
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- Changes in mechanisms of monocyte/macrophage-mediated cytotoxicity during culture. Reactive oxygen intermediates are involved in monocyte-mediated cytotoxicity, whereas reactive nitrogen intermediates are employed by macrophages in tumor cell killing.
- Morphology and lytic mechanisms of interleukin 3-dependent natural cytotoxic cells: tumor necrosis factor as a possible mediator.
- The role of activated macrophages in specific and nonspecific cytostasis of tumor cells.
- Comparison of the effects of IL-3, granulocyte-macrophage colony-stimulating factor, and macrophage colony-stimulating factor in supporting monocyte differentiation in culture. Analysis of macrophage antibody-dependent cellular cytotoxicity.
- Effect of recombinant human tumor necrosis factor on the induction of murine macrophage tumoricidal activity.
- Macrophage colony-stimulating factor (M-CSF) enhances the capacity of murine macrophages to secrete oxygen reduction products.
- The therapeutic effect of human recombinant macrophage colony stimulating factor (CSF-1) in experimental murine metastatic melanoma.
- A paracrine circuit in the regulation of the proliferation of macrophages infiltrating murine sarcomas.
- Macrophages and metastasis--a biological approach to cancer therapy.
- Role of neutrophils and CD4+ T lymphocytes in the primary and memory response to nonimmunogenic murine mammary adenocarcinoma made immunogenic by IL-2 gene.
- A safe packaging line for gene transfer: separating viral genes on two different plasmids
- Involvement of macrophages in the eradication of established metastases following intravenous injection of liposomes containing macrophage activators.
- Tumor necrosis factor is an important mediator of tumor cell killing by human monocytes.
- Cytotoxic activity and production of toxic nitrogen oxides by macrophages treated with IFN-gamma and monoclonal antibodies against the 73-kDa lipopolysaccharide receptor.
- Enhancing effect of human monocytic colony-stimulating factor on monocyte tumoricidal activity.
- Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.
- An efficient Th2-type memory follows CD8+ lymphocyte-driven and eosinophil-mediated rejection of a spontaneous mouse mammary adenocarcinoma engineered to release IL-4.
Cited by
- The Macrophage Growth Factor CSF-1 in Mammary Gland Development and Tumor Progression
- Tumour-educated macrophages promote tumour progression and metastasis
- Development of systemic immunity to glioblastoma multiforme using tumor cells genetically engineered to express the membrane-associated isoform of macrophage colony-stimulating factor.
- Macrophages kill T9 glioma tumor cells bearing the membrane isoform of macrophage colony stimulating factor through a phagocytosis-dependent pathway.
- Merkel cell polyomavirus infection and host defence in patients with Merkel cell carcinoma
- Antagonism by Ganoderma lucidum Polysaccharides Against the Suppression by Culture Supernatants of B16F10 Melanoma Cells on Macrophage
- The potential for monocyte-mediated immunotherapy during infection and malignancy. Part I: apoptosis induction and cytotoxic mechanisms.
- Antiangiogenic Drugs Synergize with a Membrane Macrophage Colony-Stimulating Factor-Based Tumor Vaccine to Therapeutically Treat Rats with an Established Malignant Intracranial Glioma1
- Macrophages that kill glioma cells expressing the membrane form of macrophage colony stimulating factor are resistant to prostaglandin E2 and interleukin-10.
- Cloning and sequencing of cDNA encoding bovine macrophage colony-stimulating factor (bM-CSF) and expression of recombinant bM-CSF using baculovirus.
- Human U251MG glioma cells expressing the membrane form of macrophage colony-stimulating factor (mM-CSF) are killed by human monocytes in vitro and are rejected within immunodeficient mice via paraptosis that is associated with increased expression of three different heat shock proteins
- Anti-Angiogenic Drugs Syngerize with a Membrane Macrophage Colony Stimulating Factor Based Tumor Vaccine to Therapeutically Treat Rats with an Established Malignant Intracranial Glioma
- The role of hypoxia and acidosis in promoting metastasis and resistance to chemotherapy.
- Non-immunogenic murine hepatocellular carcinoma Hepa1-6 cells expressing the membrane form of macrophage colony stimulating factor are rejected in vivo and lead to CD8+ T-cell immunity against the parental tumor.
- Phylogenetic analysis and prokaryotic expression of NMAAP1 derived from BCG-activated murine macrophages.
- The Phagocyte in Human Gliomas
- Expression of inflammation-mediated cluster of genes as a new marker of canine mammary malignancy
- Gene expression profiles in canine mammary carcinomas of various grades of malignancy
- A RHAMM mimetic peptide blocks hyaluronan signaling and reduces inflammation and fibrogenesis in excisional skin wounds.
- Selective deletion of the membrane-bound colony stimulating factor 1 isoform leads to high bone mass but does not protect against estrogen-deficiency bone loss
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