Synergystic induction of HIF-1α transcriptional activity by hypoxia and lipopolysaccharide in macrophages
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Summary
The results demonstrate that LPS and hypoxia act synergistically to induce HIF-1α-transcriptional activity and they emphasize the existence of a cross talk between hypoxic and non-hypoxic signaling pathways in the regulation of macrophages gene expression.
- Type
- article
- Published
- 2008-01-15
- Cited by
- 69
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W18212534
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:46050117
Keywords
Geology
References
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- Tanshinone IIA-induced attenuation of lung injury in endotoxemic mice is associated with reduction of hypoxia-inducible factor 1α expression.
- Endogenous Erythropoietin as Part of the Cytokine Network in the Pathogenesis of Experimental Autoimmune Encephalomyelitis
- Bilirubin inhibits the up-regulation of inducible nitric oxide synthase by scavenging reactive oxygen species generated by the toll-like receptor 4-dependent activation of NADPH oxidase
- Elevated Mitochondrial Reactive Oxygen Species Generation Affects the Immune Response via Hypoxia-Inducible Factor-1α in Long-Lived Mclk1+/− Mouse Mutants
- Macrophages and NF-κB in cancer.
- Macrophage Oxygen Sensing Modulates Antigen Presentation and Phagocytic Functions Involving IFN-γ Production through the HIF-1α Transcription Factor1
- Hypertonicity contributes to seawater aspiration-induced lung injury: Role of hypoxia-inducible factor 1α
- Interdependence of hypoxic and innate immune responses
- Andrographolide Inhibits PI3K/AKT-Dependent NOX2 and iNOS Expression Protecting Mice against Hypoxia/Ischemia-Induced Oxidative Brain Injury
- Hypoxia inducible factor‐1α induction by tumour necrosis factor‐α, but not by toll‐like receptor agonists, modulates cellular respiration in cultured human hepatocytes
- Identification of HIF-1α promoter and expression regulation of HIF-1α gene by LPS and hypoxia in zebrafish
- Oxygen-dependent regulation of nitric oxide production by inducible nitric oxide synthase.
- MOSCATILIN REPRESSED LIPOPOLYSACCHARIDE-INDUCED HIF-1&agr; ACCUMULATION AND NF-&kgr;B ACTIVATION IN MURINE RAW264.7 CELLS
- Monocytes and dendritic cells in a hypoxic environment: Spotlights on chemotaxis and migration.
- Prodigiosin inhibits gp91(phox) and iNOS expression to protect mice against the oxidative/nitrosative brain injury induced by hypoxia-ischemia.
- Chemotherapy not only enriches but also induces cancer stem cells
- Role of HIF-1 and NF-κB Transcription Factors in the Modulation of Transferrin Receptor by Inflammatory and Anti-inflammatory Signals*
- The purpose of the HIF-1/PHD feedback loop: To limit mTOR-induced HIF-1α
- Endotoxin-induced HIF-1α stabilisation in equine endothelial cells: synergistic action with hypoxia
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