Targeting the prostate tumor microenvironment and vasculature : the role of castration, tumor-associated macrophages and pigment epithelium-derived factor
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Summary
The mainstay treatment for patients with metastatic prostate cancer is castration, a treatment that initially provides symptom-free treatment and stays in the body for at least 12 months after diagnosis.
- Type
- article
- Published
- 2009-01-01
- Cited by
- 0
- References
- 185
- Access
- Open access
- OpenAlex
- https://openalex.org/W14332250
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:68165871
Keywords
Prostate, Epithelium, Tumor microenvironment, Prostate cancer, Pathology
References
- Inhibition of glioma invasion by overexpression of pigment epithelium-derived factor
- Characterization of the Dunning R3327H prostatic adenocarcinoma: an appropriate animal model for prostatic cancer.
- Deletion of cells by apoptosis during castration-induced involution of the rat prostate
- Neuronal differentiation of retinoblastoma cells induced by medium conditioned by human RPE cells.
- Physiology of castration-induced regression in rat prostate.
- High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20-69: an autopsy study of 249 cases.
- The hypoxic tumour microenvironment and metastatic progression
- Role of androgens in prostatic cancer.
- Treatment options for prostate cancer: evaluating the evidence.
- A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane.
- Normal histology of the prostate.
- Tumour-educated macrophages promote tumour progression and metastasis
- Hypoxia — a key regulatory factor in tumour growth
- Mechanisms of angiogenesis and arteriogenesis
- The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
- Stem cell differentiation within the human prostate epithelium: implications for prostate carcinogenesis
- Detection and characterization of circulating and disseminated prostate cancer cells.
- Plasticity of Macrophage Function during Tumor Progression: Regulation by Distinct Molecular Mechanisms1
- Hypoxia selects for androgen independent LNCaP cells with a more malignant geno‐ and phenotype
- Prolonged tumor dormancy by prevention of neovascularization in the vitreous.
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