Tumour necrosis factor-α mediates tumour promotion via a PKCα- and AP-1-dependent pathway
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Summary
Data suggest that the pro-inflammatory cytokine TNF-α is a critical mediator of tumour promotion, acting via a PKCα- and AP-1-dependent pathway, which may be one mechanism by which chronic inflammation increases susceptibility to cancer.
- Type
- article
- Published
- 2002-07-18
- Cited by
- 128
- References
- 57
- Access
- Open access
- OpenAlex
- https://openalex.org/W207000493
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28410989
Keywords
Biology, Tumor promotion, Tumor necrosis factor alpha, Carcinogenesis, Cancer research
References
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- AP1/jun function is differentially induced in promotion-sensitive and resistant JB6 cells.
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- Cellular localization of hepatic cytochrome 1B1 expression and its regulation by aromatic hydrocarbons and inflammatory cytokines.
- Tumor necrosis factor or tumor promoting factor?
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- Protein kinase C--a question of specificity.
- The role of protein kinase C in cell surface signal transduction and tumour promotion
- Induced expression of dominant‐negative c‐jun downregulates NFκB and AP‐1 target genes and suppresses tumor phenotype in human keratinocytes
- Epidermal protein kinase C-beta 2 is highly sensitive to downregulation and is exclusively expressed in Langerhans cells: downregulation is associated with attenuated contact hypersensitivity.
- Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells.
- Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas
Cited by
- The role of TNF in cancer.
- Studies on tumor promotion and progression: The importance of signaling by activator protein-1 and prostaglandin E₂
- Tumour-educated macrophages promote tumour progression and metastasis
- Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice.
- Tracking the road from inflammation to cancer: the critical role of IkappaB kinase (IKK).
- Soluble mediators of inflammation during tumor development.
- Macrophage Infiltration Induces Gastric Cancer Invasiveness by Activating the β-Catenin Pathway
- NF‐κB and cancer: Mechanisms and targets
- TNF: a tumor-suppressing factor or a tumor-promoting factor?
- Histamine suppresses fibulin-5 and insulin-like growth factor-II receptor expression in melanoma.
- Expression of both TNF-α receptor subtypes is essential for optimal skin tumour development
- TNF-α inhibits asbestos-induced cytotoxicity via a NF-κB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis
- Nuclear Factor-κB: A Holy Grail in Cancer Prevention and Therapy
- NF-κB: linking inflammation and immunity to cancer development and progression
- TNF-α and TNF-β polymorphisms with susceptibility to gastric cancer in a Korean population
- TNF-α in promotion and progression of cancer
- Suppressor role of activating transcription factor 2 (ATF2) in skin cancer
- Role of cytokines in experimentally induced lung cancer and chemoprevention by COX-2 selective inhibitor, etoricoxib
- Effect of TNF-α on Raji cells at different cellular levels estimated by various methods
- Effects of micro-environment- and malignant cell-derived interleukin-1 in carcinogenesis, tumour invasiveness and tumour-host interactions.
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