Disease-Aging Network Reveals Significant Roles of Aging Genes in Connecting Genetic Diseases
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Summary
A network-based study provides not only evidence for the intricate relationship between the aging process and genetic diseases, but also biological implications for prying into the nature of human diseases.
- Type
- article
- Published
- 2009-09-01
- Cited by
- 81
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W19779549
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31888295
Keywords
Sleep (system call), Intensity (physics), Sleep quality, Quality (philosophy), Medicine
References
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- Computational studies of gene regulatory networks: in numero molecular biology
- Possible linkage of the estrogen receptor gene to breast cancer in a family with late-onset disease.
- Further understanding human disease genes by comparing with housekeeping genes and other genes
- The signaling hubs at the crossroad of longevity and age-related disease networks.
- Systems Biology: A Brief Overview
- Systems approaches to the networks of aging.
- Evolution of ageing
- Common gene signature of cancer and longevity.
- Evidence for dynamically organized modularity in the yeast protein–protein interaction network
- Kernel-Based Data Fusion and Its Application to Protein Function Prediction in Yeast
- A Human Protein Interaction Network Shows Conservation of Aging Processes between Human and Invertebrate Species
- Hierarchical Organization of Modularity in Metabolic Networks
- A network theory of ageing: the interactions of defective mitochondria, aberrant proteins, free radicals and scavengers in the ageing process.
- A Pathway-Based View of Human Diseases and Disease Relationships
- Shortest-Path Network Analysis Is a Useful Approach toward Identifying Genetic Determinants of Longevity
- The aging process.
- Hubs with Network Motifs Organize Modularity Dynamically in the Protein-Protein Interaction Network of Yeast
- Error and attack tolerance of complex networks
Cited by
- A Hybrid Computational Method for the Discovery of Novel Reproduction-Related Genes
- Discover the network mechanisms underlying the connections between aging and age-related diseases
- Análisis de redes complejas en sistemas biomoleculares
- A systems-level approach to the evolution of ageing
- Gene regulatory network in almond (Prunus dulcis Mill.) in response to frost stress
- Integration of ‘omics’ data in aging research: from biomarkers to systems biology
- Systematic Analysis of the Associations between Adverse Drug Reactions and Pathways
- A Network of Genes, Genetic Disorders, and Brain Areas
- Disease embryo development network reveals the relationship between disease genes and embryo development genes
- Is My Network Module Preserved and Reproducible?
- Characterizing Genes with Distinct Methylation Patterns in the Context of Protein-Protein Interaction Network: Application to Human Brain Tissues
- Characterizing the Network of Drugs and Their Affected Metabolic Subpathways
- Gender-Specific DNA Methylome Analysis of a Han Chinese Longevity Population
- Complex Disease Interventions from a Network Model for Type 2 Diabetes
- Understanding the biology of aging with interaction networks.
- Systematic analysis and prediction of longevity genes in Caenorhabditis elegans.
- NOA: a novel Network Ontology Analysis method
- HPOSim: An R Package for Phenotypic Similarity Measure and Enrichment Analysis Based on the Human Phenotype Ontology
- Interconnectivity of human cellular metabolism and disease prevalence
- MicroRNA-Regulated Protein–Protein Interaction Networks: How Could They Help in Searching for Pro-Longevity Targets?
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