Characterizing the Network of Drugs and Their Affected Metabolic Subpathways
Explore this paper's citation graph
Summary
This work constructed a drug–metabolic subpathway network (DRSN) and found that if drugs were linked to the same subpathways in the DRSN, they tended to share the same indications and side effects.
- Type
- article
- Published
- 2012-10-24
- Cited by
- 34
- References
- 85
- Access
- Open access
- OpenAlex
- https://openalex.org/W1976907771
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9341852
Keywords
Drug, Drug class, Disease, Biology, Mechanism (biology)
References
- Adrenal Gland: Chemically Induced Structural and Functional Changes in the Cortex
- Disease-Aging Network Reveals Significant Roles of Aging Genes in Connecting Genetic Diseases
- Predicting ADME properties and side effects: the BioPrint approach.
- [Drug-induced gynecomastia].
- Vascular injury following accidental intra-arterial injection of clindamycin: adverse drug reaction report.
- Network biology as a new approach to drug discovery.
- Drug—target network
- Antipsychotic drugs differentially modulate apolipoprotein D in rat brain
- Mining Metabolic Networks for Optimal Drug Targets
- Systems biology, metabolic modelling and metabolomics in drug discovery and development.
- Hierarchical thinking in network biology: the unbiased modularization of biochemical networks.
- Clindamycin-induced acute cholestatic hepatitis.
- MiRNA–miRNA synergistic network: construction via co-regulating functional modules and disease miRNA topological features
- Global mapping of pharmacological space
- Antazoline-induced immune hemolytic anemia, hemoglobinuria, and acute renal failure.
- Colon perforation with acute peritonitis after taking clindamycin and diclofenac following wisdom tooth removal.
- Regulation of brain polyunsaturated fatty acid uptake and turnover.
- A Computational Approach to Analyze the Mechanism of Action of the Kinase Inhibitor Bafetinib
- Human housekeeping genes are compact.
- DrugBank: a knowledgebase for drugs, drug actions and drug targets
Cited by
- Subpathway-GM: identification of metabolic subpathways via joint power of interesting genes and metabolites and their topologies within pathways
- Computational Methods in Metabolomics
- Subpathway Analysis based on Signaling-Pathway Impact Analysis of Signaling Pathway
- A sub-pathway based method to identify candidate drugs for glioblastomas
- Identification of miRNA-Mediated Core Gene Module for Glioma Patient Prediction by Integrating High-Throughput miRNA, mRNA Expression and Pathway Structure
- A Subpathway-Based Method of Drug Reposition for Polycystic Ovary Syndrome
- Identification of potential drugs for Parkinson's disease based on a sub-pathway method
- Functional analysis of the mRNA profile of neutrophil gelatinase-associated lipocalin overexpression in esophageal squamous cell carcinoma using multiple bioinformatic tools
- Characterizing and optimizing human anticancer drug targets based on topological properties in the context of biological pathways
- Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery☆
- Cofunctional Subpathways Were Regulated by Transcription Factor with Common Motif, Common Family, or Common Tissue
- Subpathway-CorSP: Identification of metabolic subpathways via integrating expression correlations and topological features between metabolites and genes of interest within pathways
- Identification of candidate drugs for the treatment of metastatic osteosarcoma through a subpathway analysis method.
- Detecting Disease Specific Pathway Substructures through an Integrated Systems Biology Approach
- sPAGM: inferring subpathway activity by integrating gene and miRNA expression-robust functional signature identification for melanoma prognoses
- Identification of Subpathway Signatures For Ovarian Cancer Prognosis by Integrated Analyses of High-Throughput miRNA and mRNA Expression
- Integrating gene and lncRNA expression to infer subpathway activity for tumor analyses
- Identification of a robust subpathway-based signature for acute myeloid leukemia prognosis using an miRNA integrated strategy
- Identifying cancer-related microRNAs based on subpathways.
- Pathway networks generated from human disease phenome
Related papers
- Exploring the potential for using drug indications to prevent look-alike and sound-alike drug errors
- Impact of Drug Recalls on Patients in The Netherlands: A 5‐Year Retrospective Data Analysis
- Co-Prescription Trends in a Large Cohort of Subjects Predict Substantial Drug-Drug Interactions
- An update on drug-induced arthritis
- Exposure To Potential Drug-Drug Interactions in Teaching Hospital Of South Punjab, Pakistan.
- Drug-drug interactions in paediatric setting
- ABC Analysis of Drug Application in Guangzhou Red Cross Hospital in 2009
- Off-label and unlicensed drug utilization in hospitalized children in Fortaleza, Brazil
- Non-Alcoholic Fatty Liver Disease: Current Perspectives and Future Direction in Disease pathogenesis, Treatment and Diagnosis
- MicroRNAs as mediators of cardiovascular disease: Targets to be manipulated.